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Using Vaccinations to Assess In Vivo Immune Function in Psychoneuroimmunology

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Psychoneuroimmunology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 934))

Abstract

Finding clinically relevant measures of immune function is an important challenge in psychoneuroimmunological research. Here, we discuss the advantages of the vaccination model, and provide guidance on the methodological decisions that are important to consider in the use of this technique. These include the choice of vaccination, timing of assessments, and the available outcome measures.

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References

  1. Cohen S, Miller GE, Rabin BS (2001) Psychological stress and antibody response to immunization: a critical review of the human literature. Psychosom Med 63:7–18

    PubMed  CAS  Google Scholar 

  2. Burns VE, Gallagher S (2010) Antibody response to vaccination as a marker of in vivo immune function in psychophysiological research. Neurosci Biobehav Rev 35:122–126

    Article  PubMed  CAS  Google Scholar 

  3. Vedhara K, Fox JD, Wang ECY (1999) The measurement of stress-related immune dysfunction in psychoneuroimmunology. Neurosci Biobehav Rev 23:699–715

    Article  PubMed  CAS  Google Scholar 

  4. Ader R (2006) Psychoneuroimmunology. Academic, New York

    Google Scholar 

  5. Segerstrom SC, Miller GE (2004) Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 130:601–630

    Article  PubMed  Google Scholar 

  6. Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5:243–251

    Article  PubMed  CAS  Google Scholar 

  7. Phillips AC, Carroll D, Burns VE et al (2005) Neuroticism, cortisol reactivity, and antibody response to vaccination. Psychophysiology 42:232–238

    Article  PubMed  Google Scholar 

  8. Pressman SD, Cohen S, Miller GE et al (2005) Loneliness, social network size, and immune response to influenza vaccination in college freshmen. Health Psychol 24:297–306

    Article  PubMed  Google Scholar 

  9. Gallagher S, Phillips AC, Ferraro AJ et al (2008) Social support is positively associated with the immunoglobulin M response to vaccination with pneumococcal polysaccharides. Biol Psychol 78:211–215

    Article  PubMed  Google Scholar 

  10. Gallagher S, Phillips AC, Ferraro AJ et al (2008) Psychosocial factors are associated with the antibody response to both thymus-dependent and thymus-independent vaccines. Brain Behav Immun 22:456–460

    Article  PubMed  CAS  Google Scholar 

  11. Phillips AC, Burns VE, Carroll D et al (2005) The association between life events, social support, and antibody status following thymus-dependent and thymus-independent vaccinations in healthy young adults. Brain Behav Immun 19:325–333

    Article  PubMed  Google Scholar 

  12. Marsland AL, Cohen S, Rabin BS et al (2006) Trait positive affect and antibody response to hepatitis B vaccination. Brain Behav Immun 20:261–269

    Article  PubMed  CAS  Google Scholar 

  13. Edwards KM, Burns VE, Reynolds T et al (2005) Acute stress exposure prior to influenza vaccination enhances antibody response in women. Brain Behav Immun 20:159–168

    Article  PubMed  Google Scholar 

  14. Davidson RJ, Kabat-Zinn J, Schumacher J et al (2003) Alterations in brain and immune function produced by mindfulness meditation. Psychosom Med 65:564–570

    Article  PubMed  Google Scholar 

  15. Vedhara K, Bennett PD, Clark S et al (2003) Enhancement of antibody responses to influenza vaccination in the elderly following a cognitive-behavioural stress management intervention. Psychother Psychosom 72:245–252

    Article  PubMed  Google Scholar 

  16. Roitt IM, Delves PJ (2001) Essential immunology. Blackwell, Oxford

    Google Scholar 

  17. Felten DL, Felten SY, Carlson SL et al (1985) Noradrenergic and peptidergic innervation of lymphoid tissue. J Immunol 135:755–765

    Google Scholar 

  18. Sanders VM, Straub RH (2001) Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav Immun 16:290–332

    Article  Google Scholar 

  19. Nance DM, Sanders VM (2007) Autonomic innervation and regulation of the immune system (1987–2007). Brain Behav Immun 21:736–745

    Article  PubMed  CAS  Google Scholar 

  20. Miller GE, Cohen S, Pressman S et al (2004) Psychological stress and antibody response to influenza vaccination: when is the critical period for stress, and how does it get inside the body? Psychosom Med 66:215–223

    Article  PubMed  Google Scholar 

  21. Bolton DL, Roederer M (2009) Flow cytometry and the future of vaccine development. Expert Rev Vaccines 8:779–789

    Article  PubMed  CAS  Google Scholar 

  22. Couch RB, Kasel JA (1983) Immunity to influenza in man. Annu Rev Microbiol 37:529–549

    Article  PubMed  CAS  Google Scholar 

  23. Hannoun C, Megas F, Piercy J (2004) Immunogenicity and protective efficacy of influenza vaccination. Virus Res 103:133–138

    Article  PubMed  CAS  Google Scholar 

  24. Hadler SC, Francis DP, Maynard JE et al (1986) Long-term immunogenicity and efficacy of hepatitis B vaccine in homosexual men. N Engl J Med 315:209–214

    Article  PubMed  CAS  Google Scholar 

  25. Grubeck-Loebenstein B (2010) Fading immune protection in old age: vaccination in the elderly. J Comp Pathol 142(suppl 1):S116–S119

    Article  PubMed  CAS  Google Scholar 

  26. Dhabhar FS, McEwen B (1999) Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci USA 96:1059–1064

    Article  PubMed  CAS  Google Scholar 

  27. Edwards KM, Burns VE, Carroll D et al (2007) The acute stress-induced immunoenhancement hypothesis. Exerc Sport Sci Rev 35:150–155

    Article  PubMed  Google Scholar 

  28. Edwards KM, Burns VE, Adkins AE et al (2008) Meningococcal A vaccination response is enhanced by acute stress in men. Psychosom Med 70:147–151

    Article  PubMed  Google Scholar 

  29. Graham NMH, Douglas RM, Ryan P (1986) Stress and acute respiratory infection. Am J Epidemiol 124:389–401

    PubMed  CAS  Google Scholar 

  30. Meyer RJ, Haggerty RJ (1962) Streptococcal infection in families: factors altering individual susceptibility. Pediatrics 29:539–549

    PubMed  CAS  Google Scholar 

  31. Cohen S, Doyle WJ, Skoner DP (1999) Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom Med 61:175–180

    PubMed  CAS  Google Scholar 

  32. Cohen S, Tyrrell DAJ, Smith AP (1991) Psychological stress and susceptibility to the common cold. N Eng J Med 325:606–612

    Article  CAS  Google Scholar 

  33. Christian LM (2011) Psychoneuroimmunology in pregnancy: immune pathways linking stress with maternal health, adverse birth outcomes, and fetal development. Neurosci Biobehav Rev 36(1):350–361

    Article  PubMed  Google Scholar 

  34. Gallagher S, Phillips AC, Drayson MT et al (2009) Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination. Psychosom Med 71:341–344

    Article  PubMed  Google Scholar 

  35. Gallagher S, Phillips AC, Drayson MT et al (2009) Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. Brain Behav Immun 23:338–346

    Article  PubMed  Google Scholar 

  36. Govaert TME, Thijs CT, Masurel N et al (1994) The efficacy of influenza vaccination in elderly individuals. JAMA 272:1661–1665

    Article  PubMed  CAS  Google Scholar 

  37. Burns VE, Carroll D, Ring C et al (2002) Stress, coping, and hepatitis B antibody status. Psychosom Med 64:287–293

    Article  PubMed  Google Scholar 

  38. Smith TP, Kennedy SL, Fleshner M (2004) Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men. J Appl Physiol 97:491–498

    Article  PubMed  CAS  Google Scholar 

  39. Smith AJ, Bennett B, Vollmer-Conna U et al (2002) The effect of distress on the development of a primary immune response. Psychosom Med 64:166-Abstract

    Google Scholar 

  40. Edwards KM, Campbell JP, Ring C et al (2010) Exercise intensity does not influence the efficacy of eccentric exercise as a behavioural adjuvant to vaccination. Brain Behav Immun 24:623–630

    Article  PubMed  CAS  Google Scholar 

  41. Baumgarth N, Herman OC, Jager GC et al (2000) B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection. J Exp Med 192:271–280

    Article  PubMed  CAS  Google Scholar 

  42. Strauman TJ, Coe CL, McCrudden MC et al (2008) Individual differences in self-regulatory failure and menstrual dysfunction predict upper respiratory infection symptoms and antibody response to flu immunization. Brain Behav Immun 22:769–780

    Article  PubMed  Google Scholar 

  43. Glaser R, Sheridan JF, Malarkey W et al (2000) Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosom Med 62:804–807

    PubMed  CAS  Google Scholar 

  44. Maslanka SE, Gheesling LL, Libutti DE et al (1997) Standardization and a multilaboratory comparison of Neisseria meningitidis Serogroup A and C serum bactericidal assays. Clin Diag Lab Immunol 4:156–167

    CAS  Google Scholar 

  45. Goldschneider I, Gotschlich EC, Artenstein MS (1969) Human immunity to the meningococcus. I. The role of humoral antibodies. J Exp Med 129:1307–1326

    Article  PubMed  CAS  Google Scholar 

  46. Burns VE, Drayson M, Carroll D et al (2002) Antibody status following meningitis C conjugate vaccination is predicted by perceived stress and psychological well-being. Brain Behav Immun 16:173

    Google Scholar 

  47. McElhaney JE, Ewen C, Zhou X et al (2009) Granzyme B: correlates with protection and enhanced CTL response to influenza vaccination in older adults. Vaccine 27:2418–2425

    Article  PubMed  CAS  Google Scholar 

  48. Lash GE, Pinto LA (2010) Multiplex cytokine analysis technologies. Expert Rev Vaccines 9:1231–1237

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Victoria E. Burns .

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Burns, V.E. (2012). Using Vaccinations to Assess In Vivo Immune Function in Psychoneuroimmunology. In: Yan, Q. (eds) Psychoneuroimmunology. Methods in Molecular Biology, vol 934. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-071-7_19

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  • DOI: https://doi.org/10.1007/978-1-62703-071-7_19

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-070-0

  • Online ISBN: 978-1-62703-071-7

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