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The Role of Psychoneuroimmunology in Personalized and Systems Medicine

  • Qing YanEmail author
Protocol
Part of the Methods in Molecular Biology book series (MIMB, volume 934)

Abstract

Psychoneuroimmunology (PNI) may provide the scientific basis for personalized and systems medicine. The exploration of the extensive interactions among psychological and behavioral factors, the nervous system, the immune system, and the endocrine system may help understand the mechanisms underlying health, wellness, and diseases. PNI theories based on systems biology methodologies may contribute to the identification of patient patterns for establishing psychological and physiological profiles for personalized medicine. A biopsychosocial model will help elucidate the systemic interrelationships between psychosocial and bio-physiological factors for the development of systems medicine. Many evidences have supported the close relationships between stress, depression, inflammation, and disorders including obesity, cardiovascular disease, diabetes, arthritis, skin diseases, infectious diseases, and sleep disorders. As inflammation is a critical connection among different diseases, the elucidation of the associations may contribute to the findings of systemic therapeutic targets. With the understanding of the translational implications of PNI, integrative interventions in multiple dimensions can be applied to modulate stress responses and promote healthier behaviors. These interventions include combination drug therapies, diets, nutritional supplements, meditation, and other behavioral and mind-body strategies.

Key words

Brain Depression Inflammation Immune Mind-body Personalized medicine Psychoneuroimmunology Stress Systems biology Translational medicine 

References

  1. 1.
    Tausk F, Elenkov I, Moynihan J (2008) Psychoneuroimmunology. Dermatol Ther 21:22–31PubMedCrossRefGoogle Scholar
  2. 2.
    Yan Q (2011) Translation of psychoneuroimmunology into personalized medicine: a systems biology perspective. Per Med 8:641–649CrossRefGoogle Scholar
  3. 3.
    Prolo P, Chiappelli F, Fiorucci A et al (2002) Psychoneuroimmunology: new avenues of research for the twenty-first century. Ann N Y Acad Sci 966:400–408PubMedCrossRefGoogle Scholar
  4. 4.
    Yan Q (2011) Toward the integration of personalized and systems medicine: challenges, opportunities and approaches. Per Med 8:1–4CrossRefGoogle Scholar
  5. 5.
    Zachariae R (2009) Psychoneuroimmunology: a bio-psycho-social approach to health and disease. Scand J Psychol 50(6):645–651PubMedCrossRefGoogle Scholar
  6. 6.
    Kemeny ME (2009) Psychobiological responses to social threat: evolution of a psychological model in psychoneuroimmunology. Brain Behav Immun 23:1–9PubMedCrossRefGoogle Scholar
  7. 7.
    Irwin MR (2008) Human psychoneuroimmunology: 20 years of discovery. Brain Behav Immun 22:129–139PubMedCrossRefGoogle Scholar
  8. 8.
    Ader R (2000) On the development of psychoneuroimmunology. Eur J Pharmacol 405:167–176PubMedCrossRefGoogle Scholar
  9. 9.
    Leonard BE, Myint A (2009) The psychoneuroimmunology of depression. Hum Psychopharmacol 24:165–175PubMedGoogle Scholar
  10. 10.
    Ziemssen T, Kern S (2007) Psychoneuroimmunology—cross-talk between the immune and nervous systems. J Neurol 254(suppl 2):II8–II11PubMedCrossRefGoogle Scholar
  11. 11.
    Kiecolt-Glaser JK, McGuire L, Robles TF et al (2002) Psychoneuroimmunology: psychological influences on immune function and health. J Consult Clin Psychol 70:537–547PubMedCrossRefGoogle Scholar
  12. 12.
    Goncharova LB, Tarakanov AO (2007) Molecular networks of brain and immunity. Brain Res Rev 55(1):155–166PubMedCrossRefGoogle Scholar
  13. 13.
    Touma C (2011) Stress and affective disorders: animal models elucidating the molecular basis of neuroendocrine-behavior interactions. Pharmacopsychiatry 44(suppl 1):S15–S26PubMedCrossRefGoogle Scholar
  14. 14.
    Kiecolt-Glaser JK (2009) Psychoneuro-immunology psychology’s gateway to the biomedical future. Perspect Psychol Sci 4:367–369PubMedCrossRefGoogle Scholar
  15. 15.
    Fang CY, Miller SM, Bovbjerg DH et al (2008) Perceived stress is associated with impaired T-cell response to HPV16 in women with cervical dysplasia. Ann Behav Med 35:87–96PubMedGoogle Scholar
  16. 16.
    Alford L (2007) Findings of interest from immunology and psychoneuroimmunology. Man Ther 12:176–180PubMedCrossRefGoogle Scholar
  17. 17.
    Lutgendorf SK, Costanzo ES (2003) Psychoneuroimmunology and health psychology: an integrative model. Brain Behav Immun 17:225–232PubMedCrossRefGoogle Scholar
  18. 18.
    Kemeny ME, Schedlowski M (2007) Understanding the interaction between psychosocial stress and immune-related diseases: a stepwise progression. Brain Behav Immun 21:1009–1018PubMedCrossRefGoogle Scholar
  19. 19.
    Kemeny ME, Laudenslager ML (1999) Introduction beyond stress: the role of individual difference factors in psychoneuroimmunology. Brain Behav Immun 13:73–75PubMedCrossRefGoogle Scholar
  20. 20.
    Koolhaas JM (2008) Coping style and immunity in animals: making sense of individual variation. Brain Behav Immun 22:662–667PubMedCrossRefGoogle Scholar
  21. 21.
    Friedman HS (2008) The multiple linkages of personality and disease. Brain Behav Immun 22:668–675PubMedCrossRefGoogle Scholar
  22. 22.
    Friedman EM, Lawrence DA (2002) Environmental stress mediates changes in neuroimmunological interactions. Toxicol Sci 67:4–10PubMedCrossRefGoogle Scholar
  23. 23.
    Wright RJ, Subramanian SV (2007) Advancing a multilevel framework for epidemiologic research on asthma disparities. Chest 132(suppl):757S–769SPubMedCrossRefGoogle Scholar
  24. 24.
    Waye A, Trudeau VL (2011) Neuroendocrine disruption: more than hormones are upset. J Toxicol Environ Health B Crit Rev 14:270–291PubMedCrossRefGoogle Scholar
  25. 25.
    Miller GE, Chen E, Zhou ES (2007) If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol Bull 133:25–45PubMedCrossRefGoogle Scholar
  26. 26.
    Haroon E, Raison CL, Miller AH (2012) Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology 37:137–162PubMedCrossRefGoogle Scholar
  27. 27.
    Kiecolt-Glaser JK (2010) Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosom Med 72:365–369PubMedCrossRefGoogle Scholar
  28. 28.
    Liu C, Xie B, Chou CP et al (2007) Perceived stress, depression and food consumption frequency in the college students of China Seven Cities. Physiol Behav 92:748–754PubMedCrossRefGoogle Scholar
  29. 29.
    Yin J, Levanon D, Chen JDZ (2004) Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects. Neurogastroenterol Motil 16:737–744PubMedCrossRefGoogle Scholar
  30. 30.
    Stoney CM, West SG, Hughes JW et al (2002) Acute psychological stress reduces plasma triglyceride clearance. Psychophysiology 39:80–85PubMedCrossRefGoogle Scholar
  31. 31.
    Aggarwal BB, Shishodia S, Sandur SK et al (2006) Inflammation and cancer: how hot is the link? Biochem Pharmacol 72:1605–1621PubMedCrossRefGoogle Scholar
  32. 32.
    Segerstrom SC, Miller GE (2004) Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol Bull 130:1–37CrossRefGoogle Scholar
  33. 33.
    Carpenter LL, Gawuga CE, Tyrka AR et al (2010) Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults. Neuropsychopharmacology 35:2617–2623PubMedCrossRefGoogle Scholar
  34. 34.
    Kiecolt-Glaser JK, Preacher KJ, MacCallum RC et al (2003) Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci U S A 100:9090–9095PubMedCrossRefGoogle Scholar
  35. 35.
    Glaser R, Kiecolt-Glaser JK (2005) Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 5:243–251PubMedCrossRefGoogle Scholar
  36. 36.
    Yudkin JS, Kumari M, Humphries SE et al (2000) Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 148:209–214PubMedCrossRefGoogle Scholar
  37. 37.
    D’Argenio A, Mazzi C, Pecchioli L et al (2009) Early trauma and adult obesity: is psychological dysfunction the mediating mechanism? Physiol Behav 98:543–546PubMedCrossRefGoogle Scholar
  38. 38.
    Langley P, Fonseca J, Iphofen R (2006) Psychoneuroimmunology and health from a nursing perspective. Br J Nurs 15:1126–1129PubMedGoogle Scholar
  39. 39.
    Starkweather A, Witek-Janusek L, Mathews HL (2005) Applying the psychoneuroimmunology framework to nursing research. J Neurosci Nurs 37:56–62PubMedCrossRefGoogle Scholar
  40. 40.
    McCain NL, Gray DP, Walter JM et al (2005) Implementing a comprehensive approach to the study of health dynamics using the psychoneuroimmunology paradigm. ANS Adv Nurs Sci 28:320–332PubMedGoogle Scholar
  41. 41.
    DeKeyser F (2003) Psychoneuroimmunology in critically ill patients. AACN Clin Issues 14:25–32PubMedCrossRefGoogle Scholar
  42. 42.
    Shelton RC, Miller AH (2010) Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol 91:275–299PubMedCrossRefGoogle Scholar
  43. 43.
    Capuron L, Poitou C, Machaux-Tholliez D et al (2010) Relationship between adiposity, emotional status and eating behaviour in obese women: role of inflammation. Psychol Med 41:1517–1528PubMedCrossRefGoogle Scholar
  44. 44.
    Rasmusson AM, Schnurr PP, Zukowska Z, Scioli E et al (2010) Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. Exp Biol Med 235:1150–1162CrossRefGoogle Scholar
  45. 45.
    Ho RCM, Neo LF, Chua ANC et al (2010) Research on psychoneuroimmunology: does stress influence immunity and cause coronary artery disease? Ann Acad Med Singapore 39:191–196PubMedGoogle Scholar
  46. 46.
    Frasure-Smith N, Lesperance F, Irwin MR et al (2007) Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry 62:302–308PubMedCrossRefGoogle Scholar
  47. 47.
    Motivala SJ, Khanna D, FitzGerald J et al (2008) Stress activation of cellular markers of inflammation in rheumatoid arthritis: protective effects of tumor necrosis factor alpha antagonists. Arthritis Rheum 58:376–383PubMedCrossRefGoogle Scholar
  48. 48.
    Bauer-Wu SM (2002) Psychoneuroimmunology. Part II: mind-body interventions. Clin J Oncol Nurs 6:243–246PubMedCrossRefGoogle Scholar
  49. 49.
    Irwin MR, Miller AH (2007) Depressive disorders and immunity: 20 years of progress and discovery. Brain Behav Immun 21:374–383PubMedCrossRefGoogle Scholar
  50. 50.
    Giugliano D, Ceriello A, Esposito K (2006) The effects of diet on inflammation—emphasis on the metabolic syndrome. J Am Coll Cardiol 48:677–685PubMedCrossRefGoogle Scholar
  51. 51.
    Sanchez-Villegas A, Delgado-Rodriguez M, Alonso A et al (2009) Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra Follow-up (SUN) cohort. Arch Gen Psychiatry 66:1090–1098PubMedCrossRefGoogle Scholar
  52. 52.
    van West D, Maes M (2003) Polyunsaturated fatty acids in depression. Acta Neuropsychiatr 15:15–21CrossRefGoogle Scholar
  53. 53.
    Pischon T, Hankinson SE, Hotamisligil GS et al (2003) Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among U.S. men and women. Circulation 108:155–160PubMedCrossRefGoogle Scholar
  54. 54.
    Hibbeln JR, Nieminen L, Blasbalg TL et al (2006) Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr 83:1483S–1493SPubMedGoogle Scholar
  55. 55.
    Capuron L, Moranis A, Combe N et al (2009) Vitamin E status and quality of life in the elderly: influence of inflammatory processes. Br J Nutr 102:1390–1394PubMedCrossRefGoogle Scholar
  56. 56.
    Creswell JD, Myers HF, Cole SW et al (2009) Mindfulness meditation training effects on CD4+ T lymphocytes in HIV-1 infected adults: a small randomized controlled trial. Brain Behav Immun 23:184–188PubMedCrossRefGoogle Scholar
  57. 57.
    Bondolfi G, Jermann F, der Linden MV et al (2010) Depression relapse prophylaxis with mindfulness-based cognitive therapy: replication and extension in the Swiss health care system. J Affect Disord 122:224–231PubMedCrossRefGoogle Scholar
  58. 58.
    Chiesa A, Serretti A (2010) Mindfulness based cognitive therapy for psychiatric disorders: a systematic review and meta-analysis. Psychiatry Res 187:441–453PubMedCrossRefGoogle Scholar
  59. 59.
    Pace TW, Negi LT, Adame DD et al (2009) Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuro­endocrinology 34:87–98PubMedCrossRefGoogle Scholar
  60. 60.
    Tang YY, Ma Y, Fan Y et al (2009) Central and autonomic nervous system interaction is altered by short-term meditation. Proc Natl Acad Sci U S A 106:8865–8870PubMedCrossRefGoogle Scholar
  61. 61.
    Kuntsevich V, Bushell WC, Theise ND (2010) Mechanisms of yogic practices in health, aging, and disease. Mt Sinai J Med 77:559–569PubMedCrossRefGoogle Scholar
  62. 62.
    Fabricatore AN, Wadden TA, Higginbotham AJ et al (2011) Intentional weight loss and changes in symptoms of depression: a systematic review and meta-analysis. Int J Obes (Lond) 35:1363–1376CrossRefGoogle Scholar
  63. 63.
    Barbour KA, Blumenthal JA (2005) Exercise training and depression in older adults. Neurobiol Aging 26(suppl 1):119–123PubMedCrossRefGoogle Scholar
  64. 64.
    Woods JA, Vieira VJ, Keylock KT (2009) Exercise, inflammation, and innate immunity. Immunol Allergy Clin North Am 29:381–393PubMedCrossRefGoogle Scholar
  65. 65.
    Toda M, Kusakabe S, Nagasawa S et al (2007) Effect of laughter on salivary endocrinological stress marker chromogranin A. Biomed Res 28:115–118PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.PharmTaoSanta ClaraUSA
  2. 2.University of PhoenixPhoenixUSA

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