Malaria pp 371-383 | Cite as

Scoring Sporozoite Motility

  • Allison F. Carey
  • Robert MénardEmail author
  • Daniel Y. Bargieri
Part of the Methods in Molecular Biology book series (MIMB, volume 923)


Sporozoites, the stage of Plasmodium infectious to vertebrates when injected in the skin by a mosquito vector, are highly motile cells. Their unusual form of gliding motility is essential for infectivity, allowing the parasite to travel through both the mosquito and mammalian hosts, invading different cell types and escaping immune cell-mediated death. In this chapter, we describe techniques to study gliding motility of sporozoites in vitro and in vivo.

Key words

Malaria Sporozoites Gliding Motility Microscopy Imaging 



We thank Pauline Formaglio and Laura Schnettger for reading and discussing the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Allison F. Carey
    • 1
  • Robert Ménard
    • 1
    Email author
  • Daniel Y. Bargieri
    • 1
  1. 1.Unité de Biologie et Génétique du PaludismeInstitut PasteurParisFrance

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