Abstract
As an emerging model for toxicological studies, zebrafish has been explored for nanotoxicity assessment. In addition to endpoint examination of embryo/fish mortality and/or developmental disorders, molecular analyses of differential gene expression have also been employed to evaluate toxic effects associated with the exposure to nanomaterials. Here, we describe zebrafish-based assays, including both embryo and adult, for evaluation of nanotoxicity caused by metal oxide nanoparticles (NPs), in particular, zinc oxide (ZnO) and titanium oxide (TiO2) nanoparticles.
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Acknowledgments
This study was supported by the U.S. Environmental Protection Agency Science to Achieve Results Program (Grant # RD831713) (to Y.S. Chen and Y. Chang). Article contents are sole responsibility of the authors and do not represent official views of the sponsors.
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Wang, J., Zhu, X., Chen, Y., Chang, Y. (2012). Application of Embryonic and Adult Zebrafish for Nanotoxicity Assessment. In: Reineke, J. (eds) Nanotoxicity. Methods in Molecular Biology, vol 926. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-002-1_20
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DOI: https://doi.org/10.1007/978-1-62703-002-1_20
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