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Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit

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Animal Models of Acute Neurological Injuries II

Part of the book series: Springer Protocols Handbooks ((SPH))

Abstract

Focal cerebral ischemia (FCI) is a commonly used model for ischemic stroke. It induces rapid neuronal death in the ischemic core and causes a wide range of brain injury which affects cerebral cortex, striatum, hippocampus, and thalamus. In addition to the sensorimotor function deficits, FCI can also alter the cognitive function of animals. Several behavioral tests have been used to evaluate the learning and memory deficits in rodents following focal ischemia, including the Morris water maze, the passive avoidance test, and the elevated plus maze. This chapter introduces a brief history of each neurobehavioral assessment in animals following FCI, and the procedures of the tests.

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Correspondence to Dandan Sun .

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© 2012 Springer Science+Business Media, LLC

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Shi, Y., Sun, D. (2012). Neurobehavioral Assessments of Focal Cerebral Ischemia: Cognitive Deficit. In: Chen, J., Xu, XM., Xu, Z., Zhang, J. (eds) Animal Models of Acute Neurological Injuries II. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-61779-782-8_16

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  • DOI: https://doi.org/10.1007/978-1-61779-782-8_16

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-781-1

  • Online ISBN: 978-1-61779-782-8

  • eBook Packages: Springer Protocols

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