Abstract
Stroke induces long-term sensorimotor deficits that severely compromise the daily activity of patients. Experimental focal cerebral ischemia (FCI) models in rodents can exhibit certain aspects of clinical deficits in sensorimotor function following cerebral ischemia. Therefore, both histological changes and sensorimotor function can be evaluated in the experimental studies using FCI models. FCI is a common type of ischemic stroke. There are several rodent models for focal ischemia, including the ones with reperfusion (transient FCI) and those without reperfusion (permanent FCI), including endovascular filament middle cerebral artery occlusion (MCAO) model, transcranial MCAO model, and cerebrocortical photothrombosis model.
Various tests can be used to assess sensorimotor function in rodents. The rotarod test, which evaluates both the motor function and motor learning of the animals, is the most commonly used one. Other tests, including the cylinder test, adhesive removal test, and corner test, are important in investigating the asymmetric deficits caused by FCI. This chapter provides a brief introduction of each neurobehavioral assessment test on sensorimotor function and its procedures.
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Shi, Y., Sun, D. (2012). Neurobehavioral Assessments of Focal Cerebral Ischemia: Sensorimotor Deficit. In: Chen, J., Xu, XM., Xu, Z., Zhang, J. (eds) Animal Models of Acute Neurological Injuries II. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-61779-782-8_15
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DOI: https://doi.org/10.1007/978-1-61779-782-8_15
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