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Microstereolithography-Based Computer-Aided Manufacturing for Tissue Engineering

Protocol
First Online:
Part of the Methods in Molecular Biology book series (MIMB, volume 868)

Abstract

Various solid freeform fabrication technologies have been introduced for constructing three-dimensional (3-D) freeform structures. Of these, microstereolithography (MSTL) technology performs the best in 3-D space because it not only has high resolution, but also fast fabrication speed. Using this technology, 3-D structures with mesoscale size and microscale resolution are achievable. Many researchers have been trying to apply this technology to tissue engineering to construct medically applicable scaffolds, which require a 3-D shape that fits a defect with a mesoscale size and microscale inner architecture for efficient regeneration of artificial tissue. This chapter introduces the principles of MSTL technology and representative systems. It includes fabrication and computer-aided design/computer-aided manufacturing (CAD/CAM) processes to show the automation process by which measurements from medical images are used to fabricate the required 3-D shape. Then, various tissue engineering applications based on MSTL are summarized.

Key words

Microstereolithography Scaffold Tissue engineering Computer-aided design/computer-aided manufacturing 
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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Mechanical Engineering, Pohang Institute of Intelligent RoboticsPohang University of Science and Technology (POSTECH)PohangSouth Korea
  2. 2.Division of Integrative Biosciences and Biotechnology, Pohang Institute of Intelligent RoboticsPohang University of Science and Technology (POSTECH)PohangSouth Korea
  3. 3.Department of Mechanical EngineeringPohang University of Science and Technology (POSTECH)PohangSouth Korea

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