Animal Models

Part of the Methods in Molecular Biology book series (MIMB, volume 865)


Five well-established animal models in influenza research are discussed in a schematic fashion. Although there are clear parallels between these models, like viruses used, housing and handling conditions under biosafety conditions, routes of virus inoculation, sampling strategies, and necropsy techniques (mostly elaborated on in Subheading 4), each of these models involves specific differences in their practical applicability that need thorough assessment depending on the scientific question raised. In other words, there is no universal animal model for influenza and depending on the actual question to be answered the model and the experimental conditions should be carefully selected.

Key words

Influenza Animal model Mouse Ferret Guinea pig Macaque Chicken Duck Methods 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of VirologyErasmus Medical CenterRotterdamThe Netherlands

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