Wnt/Planar Cell Polarity Signaling in the Regulation of Convergent Extension Movements During Xenopus Gastrulation

  • Gun-Hwa KimEmail author
  • Edmond Changkyun Park
  • Jin-Kwan Han
Part of the Methods in Molecular Biology book series (MIMB, volume 839)


The Wnt/planar cell polarity (PCP) signaling pathway plays a critical role in wing, eye, neural tube defects, and sensory bristle development of Drosophila and vertebrate development. Recently, the Wnt/PCP pathway has been known to regulate convergent extension (CE) movements that are essential for establishing the three germ layers and body axis during early vertebrate development. Here, we describe detailed practical procedures required for the particular studies in Xenopus CE movements

Key words

Convergent extension (CE) movements Planar cell polarity (PCP) Wnt pathway Xenopus development 



We acknowledge Mi-Jung Kim and other members of our laboratory for reading this manuscript and providing constructive criticism. This work was supported by the National Research Foundation of Korea (KRF) grant (No. 20090092829) and K-MeP project (T31130) of Korea Basic Science Institute (KBSI).


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Gun-Hwa Kim
    • 1
    Email author
  • Edmond Changkyun Park
    • 1
  • Jin-Kwan Han
    • 2
  1. 1.Division of Life ScienceKorea Basic Science InstituteDaejeonRepublic of Korea
  2. 2.Division of Molecular and Life Sciences, Department of Life SciencePohang University of Science and TechnologyPohangRepublic of Korea

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