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Ubiquitin Family Modifiers and the Proteasome pp 547–576Cite as

Structural Insights into Functional Modes of Proteins Involved in Ubiquitin Family Pathways

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 832))

Abstract

The conjugation of ubiquitin and related modifiers to selected proteins represents a general mechanism to alter the function of these protein targets, thereby increasing the complexity of the cellular proteome. Ubiquitylation is catalyzed by a hierarchical enzyme cascade consisting of ubiquitin activating, ubiquitin conjugating, and ubiquitin ligating enzymes, and their combined action results in a diverse topology of ubiquitin-linkages on the modified proteins. Counteracting this machinery are various deubiquitylating enzymes while ubiquitin recognition in all its facets is accomplished by numerous ubiquitin-binding elements. In the following chapter, we attempt to provide an overview on enzymes involved in ubiquitylation as well as the removal of ubiquitin and proteins involved in the recognition and binding of ubiquitin from a structural biologist’s perspective.

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Acknowledgments

Research in the Schindelin laboratory is supported by the Deutsche Forschungsgemeinschaft (FZ 82 and SCHI 425/6-1).

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Authors and Affiliations

  1. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany

    Petra Hänzelmann, Antje Schäfer, Daniel Völler & Hermann Schindelin

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  1. Petra Hänzelmann
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  2. Antje Schäfer
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  3. Daniel Völler
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  4. Hermann Schindelin
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Correspondence to Hermann Schindelin .

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Editors and Affiliations

  1. Institut für Genetik, Universität Köln, Zülpicher Str. 47, Köln, 50674, Germany

    R. Jürgen Dohmen

  2. Fak. Biologie, Universität Konstanz, Konstanz, 78457, Germany

    Martin Scheffner

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Hänzelmann, P., Schäfer, A., Völler, D., Schindelin, H. (2012). Structural Insights into Functional Modes of Proteins Involved in Ubiquitin Family Pathways. In: Dohmen, R., Scheffner, M. (eds) Ubiquitin Family Modifiers and the Proteasome. Methods in Molecular Biology, vol 832. Humana Press. https://doi.org/10.1007/978-1-61779-474-2_39

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  • DOI: https://doi.org/10.1007/978-1-61779-474-2_39

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  • Print ISBN: 978-1-61779-473-5

  • Online ISBN: 978-1-61779-474-2

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