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Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations

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Psychiatric Disorders

Part of the book series: Methods in Molecular Biology ((MIMB,volume 829))

Abstract

The classification of psychiatric disorders has always been a problem in clinical settings. The present debate about the major systems in clinical practice, DSM-IV and ICD-10, has resulted in attempts to improve and replace those schemes by some that include more endophenotypic and molecular features. However, these disorders not only require more precise diagnostic tools, but also have to be viewed more extensively in their dynamic behaviors, which require more precise data sets related to their origins and developments. This enormous challenge in brain research has to be approached on different levels of the biological system by new methods, including improvements in electroencephalography, brain imaging, and molecular biology. All these methods entail accumulations of large data sets that become more and more difficult to interpret. In particular, on the molecular level, there is an apparent need to use highly sophisticated computer programs to tackle these problems. Evidently, only interdisciplinary work among mathematicians, physicists, biologists, and clinicians can further improve our understanding of complex diseases of the brain.

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Authors and Affiliations

  1. Kompetenzzentrum Sucht, Isar-Amper-Klinikum gemeinnützige, GmbH, Klinikum München-Ost, Haar, Germany

    Felix Tretter

  2. Department of Psychopharmacology, Central Institute for Mental Health, Mannheim, Germany

    Peter J. Gebicke-Haerter

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  1. Felix Tretter
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  2. Peter J. Gebicke-Haerter
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Correspondence to Felix Tretter .

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Editors and Affiliations

  1. McKnight Brain Institute, Department of Psychiatry, University of Florida, S. Newell Dr. 100, Gainesville, 32610, Florida, USA

    Firas H. Kobeissy

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Tretter, F., Gebicke-Haerter, P.J. (2012). Systems Biology in Psychiatric Research: From Complex Data Sets Over Wiring Diagrams to Computer Simulations. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 829. Humana Press. https://doi.org/10.1007/978-1-61779-458-2_36

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  • DOI: https://doi.org/10.1007/978-1-61779-458-2_36

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