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Animal Models of Overeating

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Psychiatric Disorders

Part of the book series: Methods in Molecular Biology ((MIMB,volume 829))

Abstract

Obesity has become a major health and economic burden, and the development of new treatments is urgently needed. Initially, such treatments involve use of animal models, and the purpose of this chapter is to describe some of the most useful models, why one might be chosen over another to address a particular question, and any procedural pitfalls. I restrict the discussion to rats and mice, used in the overwhelming majority of preclinical studies, and more specifically to protocols of diet-induced obesity and those that emulate binge eating.

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References

  1. Kaye, W. (2008) Neurobiology of anorexia and bulimia nervosa. Physiol. Behav. 94, 121 35.

    Google Scholar 

  2. Levin, B.E. (2010) Developmental gene x environment interactions affecting systems regulating energy homeostasis and obesity. Front. Neuroendocrinol. 31, 270–83.

    Article  PubMed  CAS  Google Scholar 

  3. Aleixandre de Artiñano A., Miguel Castro M. (2009). Experimental rat models to study the metabolic syndrome. Br. J. Nutr. 102, 1246–53.

    Article  PubMed  Google Scholar 

  4. Speakman J., Hambly C., Mitchell S., Król E. (2008). The contribution of animal models to the study of obesity. Lab Animal 42, 41332.

    Google Scholar 

  5. Levin, B.E., Dunn-Meynell, A.A. (2002). Defense of body weight depends on dietary composition and palatability in rats with diet-induced obesity. Am J Physiol Regulat Integ Comp Physiol 282, R46–54.

    CAS  Google Scholar 

  6. West D.B., Waguespack J., McCollister S. (1995). Dietary obesity in the mouse: interaction of strain with diet composition. Am J Physiol Regulat Integ Comp Physiol 268, R658–65.

    CAS  Google Scholar 

  7. Rothwell, N.J., Stock, M.J. (1988). The cafeteria diet as a tool for studies of thermogenesis. J Nutr. 118, 925–928.

    PubMed  CAS  Google Scholar 

  8. Bayol, S.A., Simbi, B.H., Bertrand, J.A., Strickland, N.C. (2008). Offspring from mothers fed a “junk food” diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females. J Physiol. 586, 321930.

    Google Scholar 

  9. Ackroff, K., Bonacchi, K., Magee, M., Yiin, Y-M., Graves, J.V., Sclafani, A. (2007). Obesity by choice revisted: effects of food availability, flavor variety and nutrient composition on energy intake. Physiol Behav 92, 46878.

    Google Scholar 

  10. Sclafani, A., Vigorito, M., Pfeiffer, C.L. (1988). Starch-induced overeating and overweight in rats: influence of starch type and form. Physiol Behav 42, 40915.

    Google Scholar 

  11. Mathes, C.M., Ferrara, M., Rowland, N.E. (2008). Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable food selection in a novel dessert protocol in female rats. Am J Physiol Regulat Integ Comp Physiol 295, R67–75.

    Article  CAS  Google Scholar 

  12. Levin, B.E. (1994). Diet cycling and age alter weight gain and insulin levels in rats. Am J Physiol Regulat Integ Comp Physiol 267, R527–35.

    CAS  Google Scholar 

  13. Corwin, R.L., Buda-Levin, A,. (2004). Behavioral models of binge-type eating. Physiol Behav 82, 123–30.

    Article  PubMed  CAS  Google Scholar 

  14. Rowland, N.E., Robertson, K.L. (2005). Effect of two types of environmental enrichment for singly housed mice on food intake and weight gain. Lab Animal 34, 29–32.

    PubMed  Google Scholar 

  15. Zheng, H., Shin, A.C., Lenard, N.R., Townsend, R.L., Patterson, L.M., Sigalet, D.L., Berthoud, H.R. (2009). Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. Am J Physiol Regulat Integ Comp Physiol 297, R1273–82.

    Article  CAS  Google Scholar 

  16. Rowland, N.E., Mukherjee, M., Robertson, K. (2001). Effects of the cannabinoid receptor antagonist SR141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats. Psychopharmacology 159, 111–6.

    Article  PubMed  CAS  Google Scholar 

  17. Glendinning J.I., Breinager L., Kyrillou E., Lacuna K., Rocha R., Sclafani A. (2010). Differential effects of sucrose and fructose on dietary obesity in four mouse strains. Physiol Behav 101, 331–43.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Neil E. Rowland .

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© 2012 Springer Science+Business Media, LLC

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Rowland, N.E. (2012). Animal Models of Overeating. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 829. Humana Press. https://doi.org/10.1007/978-1-61779-458-2_24

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  • DOI: https://doi.org/10.1007/978-1-61779-458-2_24

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-457-5

  • Online ISBN: 978-1-61779-458-2

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