Bioluminescence Imaging of Bone Metastasis in Rodents

  • Thomas J. A. Snoeks
  • Ermond van Beek
  • Ivo Que
  • Eric L. Kaijzel
  • Clemens W. G. M. LöwikEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 816)


Optical imaging is a valuable technique for visualizing and quantifying biological processes in living ­organisms. Optical imaging can be divided into two main imaging modalities: bioluminescence imaging and fluorescence imaging. This chapter describes the use of these imaging techniques to image tumour cells in mouse models of cancer and to detect early bone metastasis.

Key words

Fluorescent imaging Bioluminescent imaging Tumour cells Bone metastasis 


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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Thomas J. A. Snoeks
    • 1
  • Ermond van Beek
    • 1
  • Ivo Que
    • 1
  • Eric L. Kaijzel
    • 1
  • Clemens W. G. M. Löwik
    • 1
    Email author
  1. 1.Department of EndocrinologyLeiden University Medical CenterLeidenThe Netherlands

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