Analysis of Bone Architecture in Rodents Using Microcomputed Tomography
This chapter describes the use of microcomputed tomography scanning for analysing bone structure, focussing on rodent bone. It also discusses sample preparation, the correct set-up of the scanner, and the impact of some of the important scanner settings.
Key wordsX-ray 3D Rodent Computerised tomography Imaging CT Micro-CT
- 1.Hounsfield, G. N. Computerized transverse axial scanning (tomography): Part1. (1973) Description of system. Br. J. Radiol. 46, 1016–1022.Google Scholar
- 2.Sasov, A., and Van Dyck, D. (1998) Desktop X-ray microscopy and microtomography. J Microsc.; 191(Pt 2):151–158.Google Scholar
- 4.A. Daroszewska, A., Van ’t Hof, R., Rose, L,. Rose, K., and Ralston, S. (2009) The P392L Mutation of SQSTM1 Causes a Paget’s Disease-Like Phenotype In Mice. J. Bone Miner. Res. 24 (Suppl 1), S38.Google Scholar