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The Mouse Defense Test Battery: A Model Measuring Different Facets of Anxiety-Related Behaviors

  • Guy Griebel
  • Sandra Beeské
Protocol
Part of the Neuromethods book series (NM, volume 63)

Abstract

Defensive behaviors of lower mammals constitute a significant model for understanding human emotional disorders. They generally occur in response to a number of threatening stimuli, including predators, attacking conspecifics, and dangerous objects or situations. Such behaviors can readily be studied in wild rats, wild mice, or in several laboratory mice, which show a complete defensive repertoire in response to danger. Here we describe the mouse defense test battery (MDTB), which measures flight, freezing, defensive threat and attack, and risk assessment in response to an unconditioned predator stimulus, and postthreat (conditioned) defensiveness to the test context. The MDTB represents a significant improvement over other animal models for evaluating drugs active against emotional disorders since it is capable of responding to and differentiating anxiolytic drugs of different classes through specific profiles of effect on different measures.

Key words

Mouse defense test battery Anxiety Panic Defense repertoire Risk assessment Flight Defensive aggression 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Sanofi-AventisParisFrance

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