Abstract
Defensive behaviors of lower mammals constitute a significant model for understanding human emotional disorders. They generally occur in response to a number of threatening stimuli, including predators, attacking conspecifics, and dangerous objects or situations. Such behaviors can readily be studied in wild rats, wild mice, or in several laboratory mice, which show a complete defensive repertoire in response to danger. Here we describe the mouse defense test battery (MDTB), which measures flight, freezing, defensive threat and attack, and risk assessment in response to an unconditioned predator stimulus, and postthreat (conditioned) defensiveness to the test context. The MDTB represents a significant improvement over other animal models for evaluating drugs active against emotional disorders since it is capable of responding to and differentiating anxiolytic drugs of different classes through specific profiles of effect on different measures.
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References
Blanchard RJ, Flannelly KJ, Blanchard DC (1986) Defensive behavior of laboratory and wild Rattus norvegicus. J Comp Psychol 100:101–107.
Blanchard RJ, Parmigiani S, Agullana R, Weiss SM, Blanchard DC (1995) Behaviors of Swiss-Webster and C57/BL/6 N sin mice in a fear/ defense test battery. Aggress Behav 21:21–28.
Griebel G, Sanger DJ, Perrault G (1996) The Mouse Defense Test Battery: Evaluation of the effects of non-selective and BZ-1 (ω1) selective, benzodiazepine receptor ligands. Behav Pharmacol 7:560–572.
Blanchard DC, Blanchard RJ, Rodgers RJ (1991) Risk assessment and animal models of anxiety. In: Olivier B, Mos J, Slangen JL (eds) Animal Models in Psychopharmacology. Birkhauser Verlag AG, Basel.
Griebel G, Blanchard DC, Jung A, Blanchard RJ (1995) A model of ‘antipredator’ defense in Swiss-Webster mice: Effects of benzodiazepine receptor ligands with different intrinsic activities. Behav Pharmacol 6:732–745.
Griebel G, Blanchard DC, Blanchard RJ (1996) Evidence that the behaviors in the Mouse Defense Test Battery relate to different emotional states: A factor analytic study. Physiol Behav 60:1255–1260.
Blanchard RJ, Griebel G, Henrie JA, Blanchard DC (1997) Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci Biobehav Rev 21:783–789.
DSM-IV (1994) Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. American Psychiatric Association, Washington DC.
Deakin JFW, Graeff FG (1991) 5-HT and mechanisms of defense. J Psychopharmacol 5:305–315.
Graeff FG (1990) Brain defense system and anxiety. In: Burrows GD, Roth M, Noyes R, Jr. (eds) Handbook of Anxiety. vol. 3. The Neurobiology of Anxiety. Elsevier, Amsterdam.
Griebel G, Blanchard DC, Blanchard RJ (1996) Predator-elicited flight responses in Swiss-Webster mice: an experimental model of panic attacks. Prog Neuro-Psych Biol Psych 20:185–205.
Griebel G, Sanger DJ, Perrault G (1997) Genetic differences in the mouse defense test battery. Aggress Behav 23:19–31.
Blanchard DC, Griebel G, Blanchard RJ (2003) The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic. Eur J Pharmacol 463:97–116.
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Griebel, G., Beeské, S. (2011). The Mouse Defense Test Battery: A Model Measuring Different Facets of Anxiety-Related Behaviors. In: Gould, T. (eds) Mood and Anxiety Related Phenotypes in Mice. Neuromethods, vol 63. Humana Press. https://doi.org/10.1007/978-1-61779-313-4_6
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DOI: https://doi.org/10.1007/978-1-61779-313-4_6
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