Abstract
Impulsive behaviour is a fundamental component of numerous psychiatric illnesses including mood disorders. In order to measure “impulsivity” and understand the complex neurological underpinnings of this behavioural construct, it is beneficial to employ the use of mouse models. Neuropsychological tasks used to measure impulsivity in humans have been successfully translated into behavioural tests to characterise impulsivity in mice. This has lead to the development of the delayed reinforcement paradigm, which specifically measures “impulsive choice”. This, combined with genetic and pharmacological manipulations, allows insight into possible biological markers associated with impulsive choice. This chapter provides a description of the equipment and procedures required to measure impulsive choice in a delayed reinforcement paradigm, as well as examples of results and troubleshooting advice to optimise the behavioural data.
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C. A. Winstanley, D. M. Eagle, T. W. Robbins, Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clin Psychol Rev 26, 379 (Aug, 2006).
J. L. Evenden, Varieties of impulsivity. Psychopharmacology 146, 348 (1999).
A. C. Swann, M. Lijffijt, S. D. Lane, J. L. Steinberg, F. G. Moeller, Increased trait-like impulsivity and course of illness in bipolar disorder. Bipolar disorders 11, 280 (May, 2009).
A. C. Swann, Impulsivity in mania. Curr Psychiatry Rep 11, 481 (Dec, 2009).
S. Kim, D. Lee, Prefrontal cortex and impulsive decision making. Biological Psychiatry 69, 1140 (2011).
R. N. Cardinal, D. R. Pennicott, C. L. Sugathapala, T. W. Robbins, B. J. Everitt, Impulsive choice induced in rats by lesions of the nucleus accumbens core. Science 292, 2499 (2001).
S. Mobini et al., Effects of lesions of the orbitofrontal cortex on sensitivity to delayed and probabilistic reinforcement. Psychopharmacology (Berl) 160, 290 (2002).
C. A. Winstanley, D. E. Theobald, R. N. Cardinal, T. W. Robbins, Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J Neurosci 24, 4718 (May 19, 2004).
K. L. Purvis, R. Tannock, Phonological processing, not inhibitory control, differentiates ADHD and reading disability. Journal of the American Academy of Child and Adolescent Psychiatry 39, 485 (Apr, 2000).
D. M. Eagle, T. W. Robbins, Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine. Behav Neurosci 117, 1302 (Dec, 2003).
C. A. Winstanley, J. W. Dalley, D. E. Theobald, T. W. Robbins, Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behavior. Neuropsychopharmacology 29, 1331 (Jul, 2004).
A. R. Isles, T. Humby, L. S. Wilkinson, Measuring impulsivity in mice using a novel operant delayed reinforcement task: effects of behavioural manipulations and d-amphetamine. Psychopharmacology (Berl) 170, 376 (Dec, 2003).
J. Crean, J. B. Richards, H. de Wit, Effect of tryptophan depletion on impulsive behavior in men with or without a family history of alcoholism. Behav Brain Res 136, 349 (Nov 15, 2002).
J. L. Evenden, C. N. Ryan, The pharmacology of impulsive behaviour in rats: the effects of drugs on response choice with varying delays of reinforcement. Psychopharmacology (Berl) 128, 161 (1996).
A. R. Isles, T. Humby, E. Walters, L. S. Wilkinson, Common genetic effects on variation in impulsivity and activity in mice. J Neurosci 24, 6733 (Jul 28, 2004).
L. Bevilacqua et al., A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 468, 1061 (Dec 23, 2010).
D. Brunner, R. Hen, Insights into the neurobiology of impulsive behavior from serotonin receptor knockout mice. Annals of the New York Academy of Sciences 836, 81 (1997).
C. M. Helms, N. R. Gubner, C. J. Wilhelm, S. H. Mitchell, D. K. Grandy, D4 receptor deficiency in mice has limited effects on impulsivity and novelty seeking. Pharmacology, biochemistry, and behavior 90, 387 (Sep, 2008).
A. R. Isles et al., An mTph2 SNP gives rise to alterations in extracellular 5-HT levels, but not in performance on a delayed-reinforcement task. Eur J Neurosci 22, 997 (Aug, 2005).
J. C. Bizot, M. H. Thiebot, C. Le Bihan, P. Soubrie, P. Simon, Effects of imipramine-like drugs and serotonin uptake blockers on delay of reward in rats. Possible implication in the behavioral mechanism of action of antidepressants. J Pharmacol Exp Ther 246, 1144 (Sep, 1988).
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Dent, C.L., Isles, A.R. (2011). Measuring Impulsive Choice Behaviour in Mice. In: Gould, T. (eds) Mood and Anxiety Related Phenotypes in Mice. Neuromethods, vol 63. Humana Press. https://doi.org/10.1007/978-1-61779-313-4_21
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DOI: https://doi.org/10.1007/978-1-61779-313-4_21
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