Abstract
We know neuropeptides now for over 40 years as chemical signals in the brain. The discovery of neuropeptides is founded on groundbreaking research in physiology, endocrinology, and biochemistry during the last century and has been built on three seminal notions: (1) peptide hormones are chemical signals in the endocrine system; (2) neurosecretion of peptides is a general principle in the nervous system; and (3) the nervous system is responsive to peptide signals. These historical lines have contributed to how neuropeptides can be defined today: “Neuropeptides are small proteinaceous substances produced and released by neurons through the regulated secretory route and acting on neural substrates.” Thus, neuropeptides are the most diverse class of signaling molecules in the brain engaged in many physiological functions. According to this definition almost 70 genes can be distinguished in the mammalian genome, encoding neuropeptide precursors and a multitude of bioactive neuropeptides. In addition, among cytokines, peptide hormones, and growth factors there are several subfamilies of peptides displaying most of the hallmarks of neuropeptides, for example neural chemokines, cerebellins, neurexophilins, and granins. All classical neuropeptides as well as putative neuropeptides from the latter families are presented as a resource.
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References
Klavdieva, M.M. (1995) The history of neuropeptides 1. Front. Neuroendocrinol. 16, 293–321.
Klavdieva, M.M. (1996) The history of neuropeptides II. Front. Neuroendocrinol. 17, 126–153.
Klavdieva, M.M. (1996) The history of neuropeptides III. Front. Neuroendocrinol. 17, 155–179.
Klavdieva, M.M. (1996) The history of neuropeptides IV. Front. Neuroendocrinol. 17, 247–280.
Bayliss, W.M., and Starling, E.H. (1902) The mechanism of pancreatic secretion. J. Physiol. 28, 325–353.
Oliver, C., and Shäfer, E.A. (1895) On the physiological actions of extracts of the pituitary body and certain other glandular organs. J. Physiol. 18, 277–279.
Von den Velden, R. (1913) Die Nierenwirkung von Hypophysenextrakten beim Menschen. Klin. Wochschr. (Berlin) 50, 2083–2086.
Starling, E.H. (1904) The chemical regulation of the secretory process (Croonian Lecture to the Royal Society). Proc. Royal Soc. 73B, 310–322.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body I. Lancet 2, 339–341.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body II. Lancet 2, 423–425.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body III. Lancet 2, 501–503.
Starling, E.H. (1905) Croonian Lecture: On the chemical correlation of the functions of the body IV. Lancet 2, 579–583.
Von Euler, U.S., and Gaddum J.H. (1931) An unidentified depressor substance in certain tissue extracts. J. Physiol. 72, 74–87.
Du Vigneaud, V., Lawler, H.C., and Popenoe, E.A. (1953) Enzymatic cleavage of glycinamide from vasopressin and a proposed structure for this pressor-antidiuretic hormone of the posterior pituitary. J. Am. Chem. Soc. 75, 4880–4881.
Wade, N. (1981) The Nobel Duel. Doubleday, Garden City, New York.
Tatemoto, K., and Mutt, V. (1980) Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides. Nature 285, 417–418.
Hughes, J., Smith, T.W., Kosterlitz, H.W. et al (1975) Identification of two related pentapeptides from the brain with potent opiate agonist activity. Nature 258, 577–580.
Speidel, C.C. (1919) Gland-cells of internal secretion in the spinal cord of the skaes. Carengie Institute Washington Publications 13, 1–31
Scharrer, E., and Scharrer, B. (1937) Über Drüsen-Nervenzellen und neurosekretorische Organe bei Wirbellosen und Wirbeltieren. Biol. Rev. 12, 185–216.
Sterba, G. (1964) Principles of histochemical and biochemical demonstration of neurosecretion (carrier protein of oxytocin) with pseudoisocyanine. Acta Histochem. 17, 268–92.
Bargmann W, Scharrer E (1951) The site of origin of the hormones of the posterior pituitary. Am. Sci. 39, 255–259.
Hökfelt, T., Johansson, O., Ljungdahl, A., Lundberg, J.M., and Schultzberg, M. (1980) Peptidergic neurones. Nature 284, 515–521.
Bohus, B., and De Wied, D. (1966) Inhibitory and facilitatory effect of two related peptides on extinction of avoidance behavior. Science 153, 318–320.
De Wied, D. (1969) Effects of peptide hormones on behavior. In: Ganong, W.F., and Martini, L. (eds), Frontiers in neuroendocrinology. Oxford University Press, New York, pp. 97–140.
De Wied, D. (1971) Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. Nature 232, 58–60.
Brownstein, M.J. (1977) Studies of the distribution of biologically active peptides in the brain. Adv. Exp. Med. Biol. 87, 41–48.
Hur, Y.S., Kim, K.D., Paek, S.H. et al (2010) Evidence for the existence of secretory granule (dense-core vesicle)-based inositol 1,4,5-trisphosphate-dependent Ca2+ signaling system in astrocytes. PLoS One 5, e11973.
Lonka-Nevalaita, L., Lume, M., Leppanen, S. et al (2010) Characterization of the intracellular localization, processing, and secretion of two glial cell line-derived neurotrophic factor splice isoforms. J. Neurosci. 30, 11403–11413.
Brownstein, M.J., Russell, J.T., and Gainer, H. (1980) Synthesis, transport, and release of posterior pituitary hormones. Science 207, 373–378.
Tooze, S.A., and Huttner, W.B. (1990) Cell-free protein sorting to the regulated and constitutive secretory pathways. Cell 60, 837–847.
Lang, T., Wacker, I., Steyer, J. et al (1997) Ca2+−triggered peptide secretion in single cells imaged with green fluorescent protein and evanescent-wave microscopy. Neuron 18, 857–863.
Tooze, S.A., Martens, G.J., and Huttner, W.B. (2001) Secretory granule biogenesis: rafting to the SNARE. Trends Cell Biol. 11, 116–122.
Burbach, J.P.H., and Wiegant, V.M. (1990) Gene expression, biosynthesis and processing of proopiomelanocortin peptides and vasopressin. In: De Wied, D. (ed), Neuropeptides, basics and perspectives. Elsevier, Amsterdam, pp 45–103.
, S.G., Jonas, V., Rosenfeld, M.G. et al (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298, 240–244.
Nawa, H., Kotani, H., Nakanishi, S. (1984) Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. Nature 312, 729–734.
Zhao, E., Zhang, D., Basak, A. et al (2009) New insights into granin-derived peptides: evolution and endocrine roles. Gen. Comp. Endocrinol. 164, 161–174.
Braks, J.A., and Martens, G.J. (1994) 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. Cell 78, 263–273.
Ubogu, E.E., Cossoy, M.B., and Ransohoff, R.M. (2006) The expression and function of chemokines involved in CNS inflammation. Trends Pharmacol. Sci. 27, 48–55.
de Haas, A.H., van Weering, H.R., de Jong, E.K. et al (2007) Neuronal chemokines:versatile messengers in central nervous system cell interaction. Mol Neurobiol. 36, 137–151.
Miller, R.J., Rostene, W., Apartis, E. et al (2008) Chemokine action in the nervous system. J. Neurosci. 28, 11792–11795.
Huang, E.J., and Reichardt, L.F. (2001) Neurotrophins:roles in neuronal development and function. Annu. Rev. Neurosci. 24, 677–736.
Thomas, K., and Davies, A. (2005) Neurotrophins:a ticket to ride for BDNF. Curr. Biol. 15, R262-R264.
Salio, C., Averill, S., Priestley, J.V. et al (2007) Costorage of BDNF and neuropeptides within individual dense-core vesicles in central and peripheral neurons. Dev. Neurobiol. 67, 326–338.
Yang, J., Siao, C.J., Nagappan, G. et al (2009) Neuronal release of pro-BDNF. Nat. Neurosci. 12, 113–115.
Teng, H.K., Teng, K.K., Lee, R. et al (2005) Pro-BDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J. Neurosci. 25, 5455–5463.
Dicou, E, (2007) Peptides other than the neurotrophins that can be cleaved from proneurotrophins:a neglected story. Arch. Physiol. Biochem. 113, 228–233.
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Burbach, J.P.H. (2011). What Are Neuropeptides?. In: Merighi, A. (eds) Neuropeptides. Methods in Molecular Biology, vol 789. Humana Press. https://doi.org/10.1007/978-1-61779-310-3_1
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DOI: https://doi.org/10.1007/978-1-61779-310-3_1
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