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Animal Models of Movement Disorders pp 317–323Cite as

Of Rats and Patients: Some Thoughts About Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally

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Part of the book series: Neuromethods ((NM,volume 61))

Abstract

Animal behaviours that are easy to measure make great test systems for drug development, but we sometimes neglect to try to understand how their four-legged world view translates to our own. In this brief essay, I try to relate the turning behaviour that has been so useful in the development of drugs that act on Parkinsonian symptoms to the actual symptoms themselves. The thoughts led to a couple of predictions about Parkinsonian behaviour that help to link the bradykinesia that both patients and animals show. In conclusion, I suggest the general idea that dopamine acts to facilitate the learning and expression of the predicted outcomes of simple motor acts: perhaps as a different expression of the reward prediction for which dopamine is already thought to be important.

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References

  1. Fox SH, Brotchie JM. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past, present, and future. In: Bjorklund A, Cenci MA (eds). Progress in Brain Research. Amsterdam: Elsevier; 2010. pp. 133–157.

    Google Scholar 

  2. Ungerstedt U. Adipsia and Aphagia after 6-Hydroxdopamine induced Degeneration of the Nigro-striatal Dopamine System. Acta Physiol Scand Suppl 1971; 367: 95–122.

    Google Scholar 

  3. Ungerstedt U, Arbuthnott GW. Quantitative recording of rotational behaviour in rats after 6- hydroxy-dopamine lesions of the nigrostriatal dopamine system. Brain Research 1970; 24: 485–493.

    Google Scholar 

  4. Ingham CA, Hood SH, Taggart P, Arbuthnott GW. Plasticity of synapses in the rat neostriatum after unilateral lesion of the nigrostriatal dopaminergic pathway. Journal of Neuroscience 1998; 18: 4732–4743.

    Google Scholar 

  5. Stephens B, Mueller AJ, Shering AF, Hood SH, Taggart P, Arbuthnott GW et al. Evidence of a breakdown of corticostriatal connections in Parkinson’s disease. Neuroscience 2005; 132: 741–754.

    Google Scholar 

  6. Torres EM, Monville C, Gates MA, Bagga V, Dunnett SB. Improved survival of young donor age dopamine grafts in a rat model of Parkinson’s disease. Neuroscience 2007; 146: 1606–1617.

    Google Scholar 

  7. Tillerson JL, Cohen AD, Philhower J, Miller GW, Zigmond MJ, Schallert T. Forced limb-use effects on the behavioral and neurochemical effects of 6-hydroxydopamine. Journal of Neuroscience 2001; 21: 4427–4435.

    Google Scholar 

  8. Ugura-Okorie DC, Arbuthnott GW. Altered paw preference after unilateral 60hydroxydopamine injections into lateral hypothalamus. Neuropsychologia 1981; 19: 463–467.

    Google Scholar 

  9. Hamilton MH, Garcia-Munoz M, Arbuthnott GW. Separation of the motor consequences from other actions of unilateral 6-hydroxydopamine lesions in the nigrostriatal neurones of rat brain. Brain Research 1985; 348: 220–228.

    Google Scholar 

  10. Dunnett SB, Lelos M. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease. In: Bjorklund A, Cenci MA (eds). Progress in Brain Research. Amsterdam: Elsevier; 2010. pp. 35–51.

    Google Scholar 

  11. Arbuthnott GW, Attree TJ, Eccleston D, Loose RW, Martin MJ. Is adenylate cyclase the dopamine receptor? Medical Biology 1974; 52: 350–353.

    Google Scholar 

  12. Damianopoulos EN, Carey RJ. Apomorphine sensitization effects: Evidence for environmentally contingent behavioral reorganization processes. Pharmacol Biochem Behav 1993; 45: 655–663.

    Google Scholar 

  13. Herrera-Marschitz M, Arbuthnott G, Ungerstedt U. The rotational model and microdialysis: Significance for dopamine signalling, clinical studies, and beyond. Progress in Neurobiology 2010; 90: 176–189.

    Google Scholar 

  14. Schultz W, Dickinson A. Neuronal coding of prediction errors. Annual Review of Neuroscience 2000; 23: 473–500.

    Google Scholar 

  15. Plotnik M, Giladi N, Hausdorff J. A new measure for quantifying the bilateral coordination of human gait: effects of aging and Parkinson’s disease. Experimental Brain Research 2007; 181: 561–570.

    Google Scholar 

  16. Plotnik M, Giladi N, Hausdorff JM. Bilateral coordination of gait and Parkinson’s disease: the effects of dual tasking. J Neurol Neurosurg Psychiatry 2009; 80: 347–350.

    Google Scholar 

  17. Plotnik M, Giladi N, Dagan Y, Hausdorff J. Postural instability and fall risk in Parkinson’s disease: impaired dual tasking, pacing, and bilateral coordination of gait during the “ON” medication state. Experimental Brain Research 2011: 1–10.

    Google Scholar 

  18. Martin JP. The Basal Ganglia and Posture. The Basal Ganglia and Posture. Philadelphia: Lippincott; 1965.

    Google Scholar 

  19. Grafton ST, Tunik E. Human Basal Ganglia and the Dynamic Control of Force during On-Line Corrections. Journal of Neuroscience 2011; 31: 1600–1605.

    Google Scholar 

  20. Kording KP, Wolpert DM. Bayesian integration in sensorimotor learning. Nature 2004; 427: 244–247.

    Google Scholar 

  21. Wing AM, Miller E. Basal ganglia lesions and psychological analyses of the control of voluntary movement. Ciba Foundation Symposium 1984; 107: 242–257.

    Google Scholar 

  22. Steiner H, Huston JP. Control of turning behavior under apomorphine by sensory input from the face. Psychopharmacology (Berl) 1992; 109: 390–394.

    Google Scholar 

  23. Sacks, O. Epilogue pp 284, Awakenings, Vintage Books, 1999.

    Google Scholar 

  24. Briand KA, Strallow D, Hening W, Poizner H, Sereno AB. Control of voluntary and reflexive saccades in Parkinson’s disease. Experimental Brain Research 1999; 129: 38–48.

    Google Scholar 

  25. Hodgson TL, Dittrich WH, Henderson L, Kennard C. Eye movements and spatial working memory in Parkinson’s disease. Neuropsychologia 1999; 37: 927–938.

    Google Scholar 

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Acknowledgements

Thanks for many readings of this text to Marianela Garcia-Munoz as well as for the encouragement to stay with handedness as a measure. Thanks too to Steve Dunnett – the only other person with whom I have really discussed this crazy idea.

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Authors and Affiliations

  1. Brain Mechanisms for Behaviour Unit, Okinawa Institute of Science & Technology Promotion Corporation, Okinawa, Japan

    Gordon W. Arbuthnott

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  1. Gordon W. Arbuthnott
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Correspondence to Gordon W. Arbuthnott .

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Editors and Affiliations

  1. , Welsh School of Pharmacology, Cardiff University, Edward VII Avenue, Cardiff, CF10 3NB, United Kingdom

    Emma L. Lane

  2. School of Biosciences, Brain Repair Group, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, United Kingdom

    Stephen B. Dunnett

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Arbuthnott, G.W. (2011). Of Rats and Patients: Some Thoughts About Why Rats Turn in Circles and Parkinson’s Disease Patients Cannot Move Normally. In: Lane, E., Dunnett, S. (eds) Animal Models of Movement Disorders. Neuromethods, vol 61. Humana Press. https://doi.org/10.1007/978-1-61779-298-4_16

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  • DOI: https://doi.org/10.1007/978-1-61779-298-4_16

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-297-7

  • Online ISBN: 978-1-61779-298-4

  • eBook Packages: Springer Protocols

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