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MRI of the Lung: Non-invasive Protocols and Applications to Small Animal Models of Lung Disease

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In vivo NMR Imaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 771))

Abstract

Magnetic resonance imaging (MRI) can be used in pre-clinical studies as a non-invasive imaging tool for assessing the morphological and functional impact of lung diseases and for evaluating the efficacy of potential treatments for airways diseases. Hyperpolarized gases (3He or 129Xe) MRI provides insight into the lung ventilation function. Lung proton MRI provides information on lung diseases associated with inflammatory activity or with changes in lung tissue density. These imaging techniques can be implemented with non-invasive protocols appropriate for longitudinal investigations in small animal models of lung diseases. This chapter will detail two 3He and proton lung MR imaging protocols applied on two models of lung pathology in rodents.

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Acknowledgments

Magdalena Zurek acknowledges a fellowship from the European Network PHELINET (MRTN-CT-2006-36002).

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Authors and Affiliations

  1. Université Lyon 1, Creatis – LRMN, Lyon, France

    Magdalena Zurek

  2. Centre de Recherche Cardio-Thoracique, Université Bordeaux 2, 146 rue Léo-Saignat, 33076, Bordeaux, France

    Yannick Crémillieux

Authors
  1. Magdalena Zurek
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  2. Yannick Crémillieux
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Correspondence to Magdalena Zurek .

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Editors and Affiliations

  1. ERC Project BiosensorImaging, Leibniz-Institut für Molekulare Pharmako, Robert-Roessle-Str. 10, Berlin, 13125, Germany

    Leif Schröder

  2. Inst. Klinische Radiologie, AG Experimentelle, Universität Münster, Haus Rosenbach Waldeyerstr. 1, Münster, 48149, Germany

    Cornelius Faber

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Zurek, M., Crémillieux, Y. (2011). MRI of the Lung: Non-invasive Protocols and Applications to Small Animal Models of Lung Disease. In: Schröder, L., Faber, C. (eds) In vivo NMR Imaging. Methods in Molecular Biology, vol 771. Humana Press. https://doi.org/10.1007/978-1-61779-219-9_24

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  • DOI: https://doi.org/10.1007/978-1-61779-219-9_24

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