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Neurophenotyping Genetically Modified Mice for Social Behavior

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Proprotein Convertases

Part of the book series: Methods in Molecular Biology ((MIMB,volume 768))

Abstract

Sociability in mice is a multidimensional adaptive and functional response. Due to its complexity, it is important that researchers use well-defined behavioral assays that are easily replicated with clearly defined ethograms. In the Mouse Behavioral and Neuroendocrine Analysis Core Facility at Duke University, we have developed a broad series of tests that examine different components of neonatal and adult social behaviors that include sociability, sexual behavior, aggressive and territorial responses, and maternal behaviors. While the purpose of this chapter is not to provide an exhaustive description of all mouse social tests available, we provide investigators with a description of basic procedures and considerations necessary to develop a successful social behavior testing program within their laboratories.

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Acknowledgment

This work is partially supported by HD36015, MH019109, and MH082441.

Author information

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences and Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, 27710, USA

    Ramona M. Rodriguiz

  2. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27710, USA

    Jennifer S. Colvin

  3. Department of Psychiatry and Behavioral Sciences, Cell Biology, and Neurobiology, Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University Medical Center, Durham, NC, 27710, USA

    William C. Wetsel

Authors
  1. Ramona M. Rodriguiz
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  2. Jennifer S. Colvin
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  3. William C. Wetsel
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Corresponding author

Correspondence to Ramona M. Rodriguiz .

Editor information

Editors and Affiliations

  1. Chronic Disease Program, Ottawa Hospital Research Institute, Parkdale Avenue 725, Ottawa, K1Y 4E9, Ontario, Canada

    Majambu Mbikay

  2. (ICRM), Lab. Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Avenue des Pins Ouest 110, Montreal, H2W 1R7, Québec, Canada

    Nabil G. Seidah

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Rodriguiz, R.M., Colvin, J.S., Wetsel, W.C. (2011). Neurophenotyping Genetically Modified Mice for Social Behavior. In: Mbikay, M., Seidah, N. (eds) Proprotein Convertases. Methods in Molecular Biology, vol 768. Humana Press. https://doi.org/10.1007/978-1-61779-204-5_19

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  • DOI: https://doi.org/10.1007/978-1-61779-204-5_19

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-203-8

  • Online ISBN: 978-1-61779-204-5

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