Experimental Designs for the Study of Receptor–Receptor Interactions

  • Dennis PaulEmail author
Part of the Neuromethods book series (NM, volume 60)


With the rise of interest in receptor–receptor interaction research, optimization of experimental designs to study the nature of interactions has become increasingly important. In this chapter, traditional experimental designs and their associated statistics are reviewed, and their theoretical and practical limitations are described. The logic and theory behind isobolographic analysis is explained and their practical use is also described. As more and more receptor–receptor interactions are recognized with the use of two or more GPCR drugs, advances in the analysis of the type presented here will become more significant and important for clinical pharmacotherapy.

Key words

Experimental design Isobolographic analysis Synergism Additivity Interference 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Pharmacology and Experimental TherapeuticsLouisiana State University Health Sciences CenterNew OrleansUSA

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