Self-Assembly of Metal-DNA Triangles and DNA Nanotubes with Synthetic Junctions

  • Hua Yang
  • Pik Kwan Lo
  • Christopher K. McLaughlin
  • Graham D. Hamblin
  • Faisal A. Aldaye
  • Hanadi F. SleimanEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 749)


The site-specific insertion of organic and inorganic molecules into DNA nanostructures can provide unique structural and functional capabilities. We have demonstrated the inclusion of two types of molecules. The first is a diphenylphenanthroline (dpp, 1) molecule that is site specifically inserted into DNA strands and which can be used as a template to create metal-coordinating pockets. These building blocks can then be used to assemble metal-DNA 2D and 3D structures, including metal-DNA triangles, described here. The second insertion is a triaryl molecule that provides geometric control in the preparation of 2D single-stranded DNA templates. These can be designed to further assemble into geometrically well-defined nanotubes. Here, we detail the steps involved in the construction of metal-DNA triangles and DNA nanotubes using these methods.

Key words

DNA Self-assembly Nanostructure Transition metal Nanotube 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Hua Yang
  • Pik Kwan Lo
  • Christopher K. McLaughlin
  • Graham D. Hamblin
  • Faisal A. Aldaye
  • Hanadi F. Sleiman
    • 1
    Email author
  1. 1.Department of ChemistryMcGill UniversityMontrealCanada

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