DNA Nanotechnology

Volume 749 of the series Methods in Molecular Biology pp 33-47


Self-Assembly of Metal-DNA Triangles and DNA Nanotubes with Synthetic Junctions

  • Hua Yang
  • , Pik Kwan Lo
  • , Christopher K. McLaughlin
  • , Graham D. Hamblin
  • , Faisal A. Aldaye
  • , Hanadi F. SleimanAffiliated withDepartment of Chemistry, McGill University Email author 

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The site-specific insertion of organic and inorganic molecules into DNA nanostructures can provide unique structural and functional capabilities. We have demonstrated the inclusion of two types of molecules. The first is a diphenylphenanthroline (dpp, 1) molecule that is site specifically inserted into DNA strands and which can be used as a template to create metal-coordinating pockets. These building blocks can then be used to assemble metal-DNA 2D and 3D structures, including metal-DNA triangles, described here. The second insertion is a triaryl molecule that provides geometric control in the preparation of 2D single-stranded DNA templates. These can be designed to further assemble into geometrically well-defined nanotubes. Here, we detail the steps involved in the construction of metal-DNA triangles and DNA nanotubes using these methods.

Key words

DNA Self-assembly Nanostructure Transition metal Nanotube