DNA-Modified Single Crystal and Nanoporous Silicon

  • Andrew HoultonEmail author
  • Bernard A. Connolly
  • Andrew R. Pike
  • Benjamin R. Horrocks
Part of the Methods in Molecular Biology book series (MIMB, volume 749)


The functionalization of silicon as elemental crystalline wafer, nanoporous layers, or nanocrystalline particles with DNA oligonucleotides using automated solid phase synthesis is described. The procedures provide semiconductor surfaces covalently modified with oligomers suitable for capturing complementary oligonucleotide strands.

Key words

DNA Silicon Oligonucleotide Nanoporous Monolayer 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Andrew Houlton
    • 1
    Email author
  • Bernard A. Connolly
  • Andrew R. Pike
  • Benjamin R. Horrocks
  1. 1.Chemical Nanoscience Laboratory, School of ChemistryNewcastle UniversityNewcastle upon TyneUK

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