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CFTR Three-Dimensional Structure

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Cystic Fibrosis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 741))

Abstract

CFTR is a member of the ATP-binding cassette family of membrane proteins. This is one of the best characterised membrane protein families in terms of structure and function. CFTR operates as an ion channel, unlike nearly all other family members which are active transporters. Here, we discuss methods that have allowed such data to be obtained for CFTR.

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Acknowledgements

We are extremely grateful to our collaborators at the University of North Carolina (Chapel Hill) led by Professor John Riordan. Without their advice, information, resources and protein, we would not have delved into the CFTR structural world. The authors acknowledge the financial support of the Cystic Fibrosis Foundation (USA).

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Authors and Affiliations

  1. Faculty of Life Sciences, Manchester Interdisciplinary Biocentre, The University of Manchester, M1 7DN, Manchester, UK

    Robert C. Ford, James Birtley & Mark F. Rosenberg

  2. Department of Cell Biology and Physiology, University of Pittsburgh, PA, 15261, Pittsburgh, USA

    Liang Zhang

Authors
  1. Robert C. Ford
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  2. James Birtley
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  3. Mark F. Rosenberg
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  4. Liang Zhang
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Corresponding author

Correspondence to Robert C. Ford .

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Editors and Affiliations

  1. Faculty of Sciences, Centre for Biodiversity & Functional, University of Lisboa, Campo Grande, Lisboa, 1749-016, Portugal

    Margarida D. Amaral

  2. , Department of Physiology, University of Regensburg, Universitätsstr. 31, Regensburg, 93053, Germany

    Karl Kunzelmann

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Ford, R.C., Birtley, J., Rosenberg, M.F., Zhang, L. (2011). CFTR Three-Dimensional Structure. In: Amaral, M., Kunzelmann, K. (eds) Cystic Fibrosis. Methods in Molecular Biology, vol 741. Humana Press. https://doi.org/10.1007/978-1-61779-117-8_22

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  • DOI: https://doi.org/10.1007/978-1-61779-117-8_22

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61779-116-1

  • Online ISBN: 978-1-61779-117-8

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