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Neurotransmitter Transporters and Anticonvulsant Drug Development

  • Arne Schousboe
  • Karsten K. Madsen
  • H. Steve White
Protocol
Part of the Neuromethods book series (NM, volume 56)

Abstract

Excitatory and inhibitory neurotransmission mediated by glutamate and GABA, respectively, plays a major role in generation of seizures. So far, emphasis has been placed on the GABA system in attempts to develop antiepileptic drugs. Tiagabine, a selective inhibitor of GABA transporter 1 (GAT1), is marketed for treatment of certain seizure types and serves as a proof of principle that inhibitors of GABA transport may be interesting in this context. The chapter describes the methodology available to investigate in detail the pharmacology of GABA transporters and design of studies leading to identification of drug candidates. Emphasis is placed on a possible role of extrasynaptic GABA transporters in seizure control.

Key words

GABA Transporters Glutamate Neurons Astrocytes Epilepsy 

Notes

Acknowledgments

The expert secretarial assistance of Ms Hanne Danø is cordially acknowledged. The experimental work forming the basis of this review has been supported by grants from the Lundbeck Foundation (J.nr. 21/05 & R19-A2199).

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Arne Schousboe
    • 1
  • Karsten K. Madsen
  • H. Steve White
  1. 1.Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical SciencesUniversity of CopenhagenCopenhagenDenmark

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