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Identifying and Searching for Conserved RNA Localisation Signals

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Book cover RNA Detection and Visualization

Part of the book series: Methods in Molecular Biology ((MIMB,volume 714))

Abstract

RNA localisation is an important mode of delivering proteins to their site of function. Cis-acting signals within the RNAs, which can be thought of as zip-codes, determine the site of localisation. There are few examples of fully characterised RNA signals, but the signals are thought to be defined through a combination of primary, secondary, and tertiary structures. In this chapter, we describe a selection of computational methods for predicting RNA secondary structure, identifying localisation signals, and searching for similar localisation signals on a genome-wide scale. The chapter is aimed at the biologist rather than presenting the details of each of the individual methods.

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Acknowledgement

RSH and ID are supported through a Wellcome Trust Senior Research Fellowship (081858) to ID.

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  1. Department of Biochemistry, University of Oxford, Oxford, UK

    Ilan Davis

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  1. Russell S. Hamilton
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    Jeffrey E. Gerst

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Hamilton, R.S., Davis, I. (2011). Identifying and Searching for Conserved RNA Localisation Signals. In: Gerst, J. (eds) RNA Detection and Visualization. Methods in Molecular Biology, vol 714. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-005-8_27

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  • DOI: https://doi.org/10.1007/978-1-61779-005-8_27

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