Nitric Oxide pp 187-195 | Cite as

Nitric Oxide Releasing Nanoparticle Synthesis and Characterization

  • George HanEmail author
  • Adam J. Friedman
  • Joel M. Friedman
Part of the Methods in Molecular Biology book series (MIMB, volume 704)


While the potential applications of nitric oxide for both understanding human physiology and treating disease are far reaching, the development of a reliable, cost-effective, and practical sustained delivery system for nitric oxide has yet to emerge. Using a sol–gel/glass hybrid system, we have demonstrated controlled, sustained release of nitric oxide from a stable, dry powder. Upon exposure to an aqueous environment, the material begins releasing therapeutic levels of nitric oxide over several hours to days, making it an ideal material for evaluation of nitric oxide efficacy for both clinical and research applications.

Key words

Nitric oxide sol–gel nanoparticles chitosan sustained release 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • George Han
    • 1
    Email author
  • Adam J. Friedman
    • 2
  • Joel M. Friedman
    • 1
  1. 1.Department of Physiology and BiophysicsAlbert Einstein College of Medicine, Yeshiva UniversityBronxUSA
  2. 2.Division of Dermatology, Department of Physiology and BiophysicsAlbert Einstein College of Medicine, Yeshiva UniversityBronxUSA

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