Abstract
Over the past decades, transgenic and knock-out mouse models have become common use in research laboratories. Detailed phenotypic characterization of such models is essential for understanding basic mechanisms of normal physiology and disease. Hereto, pathological examination is a very helpful tool. This chapter describes detailed procedures to perform autopsy and immuno-histological analysis of mice.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsSpringer Nature is developing a new tool to find and evaluate Protocols. Learn more
References
http://www3.niaid.nih.gov/labs/aboutlabs/cmb/InfectiousDiseasePathogenesisSection/mouseNecropsy/. Information on autopsy of the mouse.
http://icg.cpmc.columbia.edu/cattoretti/Protocol/MousePathology/mainPageMousePath2.html. Information on autopsy of the mouse.
http://reni.item.fraunhofer.de/reni/trimming/index.php. Information on the trimming procedure of the tissues of the mouse.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
Gijbels, M.J.J., de Winther, M.P.J. (2011). Autopsy and Histological Analysis of the Transgenic Mouse. In: Hofker, M., van Deursen, J. (eds) Transgenic Mouse Methods and Protocols. Methods in Molecular Biology, vol 693. Humana Press. https://doi.org/10.1007/978-1-60761-974-1_5
Download citation
DOI: https://doi.org/10.1007/978-1-60761-974-1_5
Published:
Publisher Name: Humana Press
Print ISBN: 978-1-60761-973-4
Online ISBN: 978-1-60761-974-1
eBook Packages: Springer Protocols