Autopsy and Histological Analysis of the Transgenic Mouse

  • Marion J. J. GijbelsEmail author
  • Menno P. J. de Winther
Part of the Methods in Molecular Biology book series (MIMB, volume 693)


Over the past decades, transgenic and knock-out mouse models have become common use in research laboratories. Detailed phenotypic characterization of such models is essential for understanding basic mechanisms of normal physiology and disease. Hereto, pathological examination is a very helpful tool. This chapter describes detailed procedures to perform autopsy and immuno-histological analysis of mice.

Key words

Mouse models Necroscopy Immunohistochemistry Pathology 


Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Marion J. J. Gijbels
    • 1
    Email author
  • Menno P. J. de Winther
    • 1
  1. 1.Department of Molecular Genetics, Cardiovascular Research Institute MaastrichtMaastricht UniversityMaastrichtThe Netherlands

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