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Zebrafish Neurobehavioral Protocols pp 109–124Cite as

A Novel Test Battery to Assess Drug-Induced Changes in Zebrafish Social Behavior

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Part of the book series: Neuromethods ((NM,volume 51))

Abstract

The zebrafish (Danio rerio) has been at the forefront of neurobiological research and is steadily gaining favor as a model organism for behavioral applications. The ease of handling, high yield of progeny, and efficient mode of drug delivery make this species a particularly useful model for behavioral screening. Various drug classes have a range of physiological effects that can impact motor output and social behavior. Using a behavioral paradigm in drug screening can be a useful tool, from determining dose ranges and toxicity to drug-induced behavioral changes. Here we propose a novel behavioral paradigm to assess the group dynamics of zebrafish. This protocol describes methods for simple, fast, and accurate assessment of drug-induced effects on motor and social behavior.

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Acknowledgments

Special thanks to: Andrew Wooton, Catherine Hammack, John David Hosemann, and Amanda Welch for their assistance in the collection and scoring of data. The authors would also like to Deniz Uzbay, AIM for his support and counsel.

Author information

Authors and Affiliations

  1. Department of Psychology, The University of Southern Mississippi, Hattiesburg, MS, USA

    David J. Echevarria, Christina N. Toms & David J. Jouandot

  2. Department of Cell and Systems Biology, The University of Toronto, Toronto, Canada

    Christine Buske

Authors
  1. David J. Echevarria
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  2. Christine Buske
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  3. Christina N. Toms
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  4. David J. Jouandot
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Editor information

Editors and Affiliations

  1. Neuroscience Program, Department of Pharmacology, Tulane University, Tulane Ave. 1430, New Orleans, 70112, Louisiana, USA

    Allan V. Kalueff

  2. Neuroscience Program, Department of Pharmacology, Tulane University, Tulane Ave. 1430, New Orleans, 70112, Louisiana, USA

    Jonathan M. Cachat

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Echevarria, D.J., Buske, C., Toms, C.N., Jouandot, D.J. (2011). A Novel Test Battery to Assess Drug-Induced Changes in Zebrafish Social Behavior. In: Kalueff, A., Cachat, J. (eds) Zebrafish Neurobehavioral Protocols. Neuromethods, vol 51. Humana Press. https://doi.org/10.1007/978-1-60761-953-6_9

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  • DOI: https://doi.org/10.1007/978-1-60761-953-6_9

  • Published:

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-952-9

  • Online ISBN: 978-1-60761-953-6

  • eBook Packages: Springer Protocols

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