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Penetratin Story: An Overview

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Cell-Penetrating Peptides

Part of the book series: Methods in Molecular Biology ((MIMB,volume 683))

Abstract

Cell-penetrating peptides are short, often hydrophilic peptides that get access to the intracellular milieu. They have aroused great interest both in academic and applied research. First, cellular internalization of CPPs often involves the crossing of a biological membrane (plasma or vesicular), thus challenging the view of the nonpermeability of these structures to large hydrophilic molecules. Secondly, CPPs can drive the internalization of hydrophilic cargoes into cells, a rate-limiting step in the development of many therapeutic substances. Interestingly, the two mostly used CPPs, TAT and Penetratin peptides, are derived from natural proteins, HIV Tat and Antennapedia homeoprotein, respectively. The identification of the Penetratin peptide, summarized in this review, is intimately linked to the study of its parental natural protein.

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Author information

Authors and Affiliations

  1. Homeoprotein Cell Biology, Ecole normale supérieure and Collège de France, Paris, France

    Edmond Dupont

  2. Chaire des processus morphogénétiques, Ecole normale supérieure and Collège de France, Paris, France

    Alain Prochiantz

  3. Ecole Normale Supérieure, Paris, France

    Alain Joliot

Authors
  1. Edmond Dupont
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  2. Alain Prochiantz
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  3. Alain Joliot
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Corresponding author

Correspondence to Alain Joliot .

Editor information

Editors and Affiliations

  1. , Department of Neurochemistry, Stockholm University, Svante Arrheniusv 21A21A, Stockholm, 106 91, Sweden

    Ülo Langel

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Dupont, E., Prochiantz, A., Joliot, A. (2011). Penetratin Story: An Overview. In: Langel, Ü. (eds) Cell-Penetrating Peptides. Methods in Molecular Biology, vol 683. Humana Press. https://doi.org/10.1007/978-1-60761-919-2_2

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  • DOI: https://doi.org/10.1007/978-1-60761-919-2_2

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60761-918-5

  • Online ISBN: 978-1-60761-919-2

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