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Animal Models of HIV-Associated Painful Sensory Neuropathy

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Animal Models of Pain

Part of the book series: Neuromethods ((NM,volume 49))

Abstract

Painful distal sensory neuropathy is the most common neurological complication of HIV1 infection. There are several neuropathic pain syndromes associated with the disease; however, the most common is a sensory neuropathy called HIV sensory neuropathy (HIV-SN). HIV-SN can be subdivided into subacute or chronic distal sensory polyneuropathy (DSP) and subacute antiretroviral-induced toxic neuropathy (ATN). Both forms involve sensory loss and neuropathic pain. DSP occurs in up to 7–35% of HIV1-infected individuals and upwards of 34% of children infected with HIV1, while ATN develops following highly active antiretroviral therapy (HAART) treatment in up to 52% of patients. The mechanisms of HIV-SN remain unclear; however, the advent of several models of HIV1-associated peripheral neuropathy is helping unlock the mysteries surrounding HIV-SN. This chapter describes the known pathology of HIV1 and the resulting neuropathy syndromes, including descriptions of the models used to study this particular type of neuropathic pain.

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Author information

Authors and Affiliations

  1. Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    Sonia K. Bhangoo

  2. Department of Anesthesia, Indiana University School of Medicine, Stark Neuroscience Research Institute, Indianapolis, IN, USA

    Lauren Petty & Fletcher A. White

Authors
  1. Sonia K. Bhangoo
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  2. Lauren Petty
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  3. Fletcher A. White
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Corresponding author

Correspondence to Fletcher A. White .

Editor information

Editors and Affiliations

  1. , Department of Anesthesiology, Yale University School of Medicine, Cedar Street 333, New Haven, 06520-8051, Connecticut, USA

    Chao Ma

  2. College of Medicine, Department of Anesthesiology, University of Cincinnati, Albert Sabin Way 231, Cincinnati, 45267-0531, Ohio, USA

    Jun-Ming Zhang

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Bhangoo, S.K., Petty, L., White, F.A. (2011). Animal Models of HIV-Associated Painful Sensory Neuropathy. In: Ma, C., Zhang, JM. (eds) Animal Models of Pain. Neuromethods, vol 49. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-880-5_10

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  • DOI: https://doi.org/10.1007/978-1-60761-880-5_10

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-879-9

  • Online ISBN: 978-1-60761-880-5

  • eBook Packages: Springer Protocols

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