Drug Safety Evaluation

Volume 691 of the series Methods in Molecular Biology pp 39-67


Necropsy and Sampling Procedures in Rodents

  • Laurence FietteAffiliated withHuman Histopathology and Animal Models Unit, Institut Pasteur
  • , Mohamed SlaouiAffiliated withDisposition, Safety and Animal Research, sanofi-aventis R&D Email author 

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Necropsy is a major step of most studies using laboratory animals. During necropsy, tissue and organ changes noticeable grossly can be recorded, and important tissue samples can be stored for subsequent evaluation. It is therefore important that the personnel in charge of this key experimentation step be adequately trained and aware of the study endpoints.

Key words

Necropsy Histology Macroscopy Sampling Rodents Mouse Rat