Abstract
Systems Biology approaches to drug discovery largely focus on the increasing understanding of intracellular and cellular circuits, by computational representation of a molecular system followed by parameter validation against experimental data. This chapter outlines a universal approach to systems biology that allows the linking of intracellular molecular machinery and cellular activity. This procedure is achieved by applying mathematical modeling to molecular modules of a cell in the light of systems biology techniques.
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Valeyev, N.V., Bates, D.G., Umezawa, Y., Gizatullina, A.N., Kotov, N.V. (2010). Systems Biology of Cell Behavior. In: Yan, Q. (eds) Systems Biology in Drug Discovery and Development. Methods in Molecular Biology, vol 662. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-800-3_4
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DOI: https://doi.org/10.1007/978-1-60761-800-3_4
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