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Membrane Protein Fragments Reveal Both Secondary and Tertiary Structure of Membrane Proteins

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Membrane Protein Structure Determination

Part of the book series: Methods in Molecular Biology ((MIMB,volume 654))

Abstract

Structural data on membrane proteins, while crucial to understanding cellular function, are scarce due to difficulties in applying to membrane proteins the common techniques of structural biology. Fragments of membrane proteins have been shown to reflect, in many cases, the secondary structure of the parent protein with fidelity and are more amenable to study. This chapter provides many examples of how the study of membrane protein fragments has provided new insight into the structure of the parent membrane protein.

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Authors and Affiliations

  1. Office of the Dean of Arts & Sciences, Rutgers University, Newark, NJ, USA

    Philip L. Yeagle

  2. Department of Molecular & Cell Biology, University of Connecticut, Storrs, CT, USA

    Arlene D. Albert

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  1. Philip L. Yeagle
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  2. Arlene D. Albert
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Correspondence to Philip L. Yeagle .

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Editors and Affiliations

  1. , Université Paris Diderot - Paris 7, INSERM U773/CRB3, rue Henri Huchard 16, Paris, 75018, France

    Jean-Jacques Lacapère

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Yeagle, P.L., Albert, A.D. (2010). Membrane Protein Fragments Reveal Both Secondary and Tertiary Structure of Membrane Proteins. In: Lacapère, JJ. (eds) Membrane Protein Structure Determination. Methods in Molecular Biology, vol 654. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-762-4_15

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  • DOI: https://doi.org/10.1007/978-1-60761-762-4_15

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  • Publisher Name: Humana Press, Totowa, NJ

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