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Stem Cells for Myocardial Regeneration pp 65–84Cite as

Mesenchymal Stem Cell Therapy for Cardiac Repair

Part of the Methods in Molecular Biology book series (MIMB,volume 660)

Abstract

Stem cell therapy for repair of damaged cardiac tissue is an attractive option to improve the health of the growing number of heart failure patients. Mesenchymal stem cells (MSCs) possess unique properties that may make them a better option for cardiac repair than other cell types. Unlike other adult stem cells, they appear to escape allorecognition by the immune system and they have immune-modulating properties, thus making it possible to consider them for use as an allogeneic cell therapy product. There is a large and growing body of preclinical and early clinical experience with MSC therapy that shows great promise in realizing the potential of stem cell therapy to effect repair of damaged cardiac tissue. This review discusses the mechanism of action of MSC therapy and summarizes the current literature in the field.

Key words

  • Mesenchymal stem cell
  • Heart failure
  • Myocardial infarction
  • Cell therapy

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Authors and Affiliations

  1. Cardiology Division, Department of Medicine, University of California, San Francisco, CA, USA

    Andrew J. Boyle MBBS, PhD

  2. Interdisciplinary Stem Cell Institute and Division of Cardiology, University of Miami Miller School of Medicine, Miami, FL, USA

    Ian K. McNiece PhD & Joshua M. Hare MD

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  1. Andrew J. Boyle MBBS, PhD
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  2. Ian K. McNiece PhD
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  3. Joshua M. Hare MD
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Correspondence to Andrew J. Boyle MBBS, PhD .

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  1. , Division of Cardiology, University of California, San Francisco, 500 Parnassus Avenue, San Francisco, 94143-1354, California, USA

    Randall J. Lee

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Boyle, A.J., McNiece, I.K., Hare, J.M. (2010). Mesenchymal Stem Cell Therapy for Cardiac Repair. In: Lee, R. (eds) Stem Cells for Myocardial Regeneration. Methods in Molecular Biology, vol 660. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-705-1_5

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  • DOI: https://doi.org/10.1007/978-1-60761-705-1_5

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