Volume 640 of the series Methods in Molecular Biology pp 167-179


Hepatic Stem Cells

  • Robert E. SchwartzAffiliated withDepartment of Gastroenterology and Hepatology, Brigham and Women’s Hospital Email author 
  • , Catherine VerfaillieAffiliated withInterdepartementaal Stamcelinstituut

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Early studies in hepatocyte turnover and liver regeneration showed that the parenchymal cell, the hepatocyte, was the primary and only cell involved in tissue renewal. However, new studies of liver regeneration, hepatocarcinogenesis, liver transplantation, and various cell lines have shown that a variety of cell types participate in maintaining hepatocyte number and mass and question the dogma of the previous hierarchy of hepatocyte differentiation in vitro and in vivo.

Key words

Hepatocytes hepatic stem cells development stem cell plasticity liver regeneration