Review of Human DC Subtypes

  • Xinsheng Ju
  • Georgina Clark
  • Derek N.J. Hart
Part of the Methods in Molecular Biology book series (MIMB, volume 595)


Dendritic cells (DC) are critical to the induction and regulation of the innate and adaptive immune responses. They have been implicated in the pathogenesis of many autoimmune and chronic inflammatory diseases as well as contributing to the development of tumours by their lack of appropriate function. As such, understanding human DC biology provides the insight needed to develop applications for their use in the treatment of diseases. Currently, studies on mouse DC outnumber those on human cells; however, the comparison between mouse and human models has been somewhat misleading due to the basic biological and practical differences between the two models. In this review, we summarise the current understanding of human DC subtypes by describing the phenotype of the populations and how this relates to function. We also hope to clarify the differences in nomenclature between the human and mouse models that have arisen by way of the different experimental models.

Key words

Dendritic cells monocytes langerhans cells subsets precursor phenotype 


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Copyright information

© Humana Press, a part of Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Xinsheng Ju
    • 1
  • Georgina Clark
    • 1
  • Derek N.J. Hart
    • 1
  1. 1.Mater Medical Research InstituteSouth BrisbaneAustralia

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