Abstract
Respiratory tract infections remain among the most common clinical problems worldwide. Pneumonia or inflammation of the lungs can be caused by infection with bacteria, viruses, and other organisms. Pneumonia management has been challenged by the widespread distribution of antibiotic-resistant strains of Streptococcus pneumoniae, the commonest cause of community acquired pneumonia. Experimental models of pneumonia have played a crucial role for testing the efficacy of antimicrobial agents as well as for gaining a better understanding of the disease pathogenesis. These models have also received increased attention as tools for deriving pharmacodynamic data and for determining the clinical significance of drug resistance.
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References
Austrian, R. (1999) The pneumococcus at the millennium: not down, not out. J Infect Dis. 179 Suppl 2, S338–S341.
Ortqvist, A., Hedlund, J., and Kalin, M. (2005) Streptococcus pneumoniae: epidemiology, risk factors, and clinical features. Semin Respir Crit Care Med. 26, 563–574.
Chiavolini, D., Pozzi, G., and Ricci, S. 2008. Animal models of Streptococcus pneumoniaedisease. Clin Microbiol Rev. 21, 666–685.
Craig, W. A. (1998) Pharmacokinetic/ pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 26, 1–10.
Moine, P., Vallée, E., Azoulay-Dupuis, E., Bourget, P., Bédos, J. P., Bauchet, J., and Pocidalo, J. J. (1994) In vivo efficacy of a broad-spectrum cephalosporin, ceftriaxone, against penicillin-susceptible and -resistant strains of Streptococcus pneumoniae in a mouse pneumonia model. Antimicrob Agents Chemother. 38, 1953–1958.
Steinhoff, M.C. (2007) Pneumococcal vaccine animal model consensus group. Animal models for protein pneumococcal vaccine evaluation: a summary, Vaccine 25, 2465–2470.
Kadioglu, A. and Andrew, P. W. (2005) Susceptibility and resistance to pneumococcal disease in mice. Brief Funct Genomic Proteomic. 4, 241–247.
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Medina, E. (2010). Murine Model of Pneumococcal Pneumonia. In: Proetzel, G., Wiles, M. (eds) Mouse Models for Drug Discovery. Methods in Molecular Biology, vol 602. Humana Press. https://doi.org/10.1007/978-1-60761-058-8_22
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DOI: https://doi.org/10.1007/978-1-60761-058-8_22
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