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Imaging of siRNA Delivery and Silencing

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siRNA and miRNA Gene Silencing

Part of the book series: Methods in Molecular Biology ((MIMB,volume 487))

Abstract

The fast developing field of RNA interference (RNAi) requires monitoring of small interfering RNA (siRNA) delivery to targeted organs and evaluating the efficiency of target gene silencing. The molecular imaging approach fits perfectly to fulfill these needs and provides information in a fast, reproducible, and noninvasive manner. This review serves as a first attempt to summarize existing information on various imaging modalities and their application for siRNA imaging. It is noteworthy that new publications in this field appear almost on a weekly basis and the authors have made a sincere attempt to reflect the development of this area in their review.

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Authors and Affiliations

  1. Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, A. Moore Massachusetts General Hospital/Harvard Medical School, Rm. 2301, Bldg.149, 13th St.,, Charlestown, , Massachusetts, 02129

    Anna Moore  & Zdravka Medarova

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  1. Anna Moore
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  2. Zdravka Medarova
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Editors and Affiliations

  1. Institute for Cancer Research, Dept. Immunology, Norwegian Radium Hospital, Montebello, Oslo, 0310, Norway

    Mouldy Sioud

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Moore , A., Medarova , Z. (2009). Imaging of siRNA Delivery and Silencing. In: Sioud, M. (eds) siRNA and miRNA Gene Silencing. Methods in Molecular Biology, vol 487. Humana Press. https://doi.org/10.1007/978-1-60327-547-7_5

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  • DOI: https://doi.org/10.1007/978-1-60327-547-7_5

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