Energy Intake, Physical Activity, Energy Balance, and Cancer: Epidemiologic Evidence

  • Sai Yi Pan
  • Marie DesMeules
Part of the Methods in Molecular Biology book series (MIMB, volume 472)

Abstract

Energy intake, physical activity, and obesity are modifiable lifestyle factors. This chapter reviews and summarizes the epidemiologic evidence on the relation of energy intake, physical activity, and obesity to cancer. High energy intake may increase the risk of cancers of colon —rectum, prostate (especially advanced prostate cancer), and breast. However, because physical activity, body size, and metabolic efficiency are highly related to total energy intake and expenditure, it is difficult to assess the independent effect of energy intake on cancer risk. There are sufficient evidences to support a role of physical activity in preventing cancers of the colon and breast, whereas the association is stronger in men than in women for colon cancer and in postmenopausal than in premenopausal women for breast cancer. The evidence also suggests that physical activity likely reduces the risk of cancers of endometrium, lung, and prostate (to a lesser extent). On the other hand, there is little or no evidence that the risk of rectal cancer is related to physical activity, whereas the results have been inconsistent regarding the association between physical activity and the risks of cancers of pancreas, ovary and kidney. Epidemiologic studies provide sufficient evidence that obesity is a risk factor for both cancer incidence and mortality. The evidence supports strong links of obesity with the risk of cancers of the colon, rectum, breast (in postmenopau-sal women), endometrium, kidney (renal cell), and adenocarcinoma of the esophagus. Epidemiologic evidence also indicates that obesity is probably related to cancers of the pancreas, liver, and gallbladder, and aggressive prostate cancer, while it seems that obesity is not associated with lung cancer. The role of obesity in other cancer risks is unclear.

Key words

Energy intake/restriction physical activity energy balance obesity overweight cancer colon rectum breast prostate lung endometrium esophagus pancreas ovary kidney liver gallbladder 

References

  1. 1.
    Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 54: 131–152.PubMedGoogle Scholar
  2. 2.
    Patel AC, Nunez NP, Perkins SN, Barrett JC, Hursting SD (2004) Effects of energy balance on cancer in genetically altered mice. J Nutr 134: 3394S–3398S.PubMedGoogle Scholar
  3. 3.
    Lane MA, Black A, Handy A, Tilmont EM, Ingram DK, Roth GS (2001) Caloric restriction in primates. Ann N ν Acad Sci 928: 287–295.Google Scholar
  4. 4.
    Roth GS, Ingram DK, Lane MA (1999) Calorie restriction in primates: will it work and how will we know? J Am Geriatr Soc 47: 896–903.PubMedGoogle Scholar
  5. 5.
    Dirx MJ, Zeegers MP, Dagnelie PC, van den Bogaard T, van den Brandt PA (2003) Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. Int J Cancer 106: 766–770.PubMedGoogle Scholar
  6. 6.
    Cleary MP, Hu X, Grossmann ME, et al. (2007) Prevention of mammary tumorigenesis by intermittent caloric restriction: does caloric intake during refeeding modulate the response? Exp Biol Med (Maywood) 232: 70–80.Google Scholar
  7. 7.
    Kritchevsky D (1997) Caloric restriction and experimental mammary carcinogenesis. Breast Cancer Res Treat 46: 161–167.PubMedGoogle Scholar
  8. 8.
    Thompson HJ, Jiang W, Zhu Z (1999) Mechanisms by which energy restriction inhibits carcinogenesis. Adv Exp Med Biol 470: 77–84.PubMedGoogle Scholar
  9. 9.
    Loft S, Velthuis-te Wierik EJ, Van den BH, Poulsen HE (1995) Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomarkers Prev 4: 515–519.PubMedGoogle Scholar
  10. 10.
    Elias SG, Peeters PH, Grobbee DE, Van Noord PA (2005) The 1944–1945 Dutch famine and subsequent overall cancer incidence. Cancer Epidemiol Biomarkers Prev 14: 1981–1985.PubMedGoogle Scholar
  11. 11.
    Frankel S, Gunnell DJ, Peters TJ, Maynard M, Davey SG (1998) Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study. BMJ 316: 499–504.PubMedGoogle Scholar
  12. 12.
    Uauy R, Solomons N (2005) Diet, nutrition, and the life-course approach to cancer prevention. J Nutr 135: 2934S–2945S.PubMedGoogle Scholar
  13. 13.
    Elias SG, Peeters PH, Grobbee DE, Van Noord PA (2004) Breast cancer risk after caloric restriction during the 1944–1945 Dutch famine. J Natl Cancer Inst 96: 539–546.PubMedGoogle Scholar
  14. 14.
    Robsahm TE, Tretli S (2002) Breast cancer incidence in food- vs non-food-producing areas in Norway: possible beneficial effects of World War II. Br J Cancer 86: 362–366.PubMedGoogle Scholar
  15. 15.
    Nilsen TI, Vatten LJ (2001) Adult height and risk of breast cancer: a possible effect of early nutrition. Br J Cancer 85: 959 –961.PubMedGoogle Scholar
  16. 16.
    Tretli S, Gaard M (1996) Lifestyle changes during adolescence and risk of breast cancer: an ecologic study of the effect of World War II in Norway. Cancer Causes Control 7: 507–512.PubMedGoogle Scholar
  17. 17.
    Vatten LJ, Kvinnsland S (1990) Body height and risk of breast cancer. A prospective study of 23,831 Norwegian women. Br J Cancer 61: 881–885.PubMedGoogle Scholar
  18. 18.
    Dirx MJ, van den Brandt PA, Goldbohm RA, Lumey LH (1999) Diet in adolescence and the risk of breast cancer: results of the Netherlands Cohort Study. Cancer Causes Control 10: 189–199.PubMedGoogle Scholar
  19. 19.
    Michels KB, Ekbom A (2004) Caloric restriction and incidence of breast cancer. JAMA 291: 1226–1230.PubMedGoogle Scholar
  20. 20.
    Varela G, Carbajal A, Nunez C, Belmonte S, Moreiras O (1996) (Influence of energy intake and body mass index in the incidence of cancer of the breast. Case-control study in a sample from 3 Spanish hospital populations). Nutr Hosp 11: 54–58.PubMedGoogle Scholar
  21. 21.
    Malin A, Matthews CE, Shu XO, et al. (2005) Energy balance and breast cancer risk. Cancer Epidemiol Biomarkers Prev 14: 1496–1501.PubMedGoogle Scholar
  22. 22.
    Franceschi S, Favero A, Decarli A, et al. (1996) Intake of macronutrients and risk of breast cancer. Lancet 347: 1351–1356.PubMedGoogle Scholar
  23. 23.
    Levi F, La VC, Gulie C, Negri E (1993) Dietary factors and breast cancer risk in Vaud, Switzerland. Nutr Cancer 19: 327–335.PubMedGoogle Scholar
  24. 24.
    Toniolo P, Riboli E, Protta F, Charrel M, Cappa AP (1989) Calorie-providing nutrients and risk of breast cancer. J Natl Cancer Inst 81: 278–286.PubMedGoogle Scholar
  25. 25.
    Yu SZ, Lu RF, Xu DD, Howe GR (1990) A case-control study of dietary and non-dietary risk factors for breast cancer in Shanghai. Cancer Res 50: 5017–5021.PubMedGoogle Scholar
  26. 26.
    Nkondjock A, Robidoux A, Paredes Y, Narod SA, Ghadirian P (2006) Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Breast Cancer Res Treat 98 : 285–294.PubMedGoogle Scholar
  27. 27.
    Levi F, Pasche C, Lucchini F, La VC (2001) Dietary intake of selected micronutrients and breast-cancer risk. Int J Cancer 91: 260–263.PubMedGoogle Scholar
  28. 28.
    Iscovich JM, Iscovich RB, Howe G, Shiboski S, Kaldor JM (1989) A case-control study of diet and breast cancer in Argentina. Int J Cancer 44: 770–776.PubMedGoogle Scholar
  29. 29.
    Fioretti F, Tavani A, Bosetti C, et al. (1999) Risk factors for breast cancer in nulliparous women. Br J Cancer 79: 1923–1928.PubMedGoogle Scholar
  30. 30.
    Chang SC, Ziegler RG, Dunn B, et al. (2006) Association of energy intake and energy balance with postmenopausal breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev 15: 334–341.PubMedGoogle Scholar
  31. 31.
    Silvera SA, Jain M, Howe GR, Miller AB, Rohan TE (2006) Energy balance and breast cancer risk: a prospective cohort study. Breast Cancer Res Treat 97: 97–106.PubMedGoogle Scholar
  32. 32.
    Barrett-Connor E, Friedlander NJ (1993) Dietary fat, calories, and the risk of breast cancer in postmenopausal women: a prospective population-based study. J Am Coll Nutr 12: 390–399.PubMedGoogle Scholar
  33. 33.
    Gaard M, Tretli S, Loken EB (1995) Dietary fat and the risk of breast cancer: a prospective study of 25,892 Norwegian women. Int J Cancer 63: 13–17.PubMedGoogle Scholar
  34. 34.
    Graham S, Hellmann R, Marshall J, et al. (1991) Nutritional epidemiology of postmenopausal breast cancer in western New York. Am J Epidemiol 134: 552–566.PubMedGoogle Scholar
  35. 35.
    Holmberg L, Ohlander EM, Byers T, et al. (1994) Diet and breast cancer risk. Results from a population-based, case-control study in Sweden. Arch Intern Med 154: 1805–1811.PubMedGoogle Scholar
  36. 36.
    Yuan JM, Wang QS, Ross RK, Henderson BE, Yu MC (1995) Diet and breast cancer in Shanghai and Tianjin, China. Br J Cancer 71: 1353–1358.PubMedGoogle Scholar
  37. 37.
    Velie E, Kulldorff M, Schairer C, Block G, Albanes D, Schatzkin A (2000) Dietary fat, fat subtypes, and breast cancer in postmen-opausal women: a prospective cohort study. J Natl Cancer Inst 92: 833–839.PubMedGoogle Scholar
  38. 38.
    Byrne C, Rockett H, Holmes MD (2002) Dietary fat, fat subtypes, and breast cancer risk: lack of an association among postmen-opausal women with no history of benign breast disease. Cancer Epidemiol Biomarkers Prev 11: 261–265.PubMedGoogle Scholar
  39. 39.
    Kim EH, Willett WC, Colditz GA, et al. (2006) Dietary fat and risk of postmeno-pausal breast cancer in a 20-year follow-up. Am J Epidemiol 164: 990–997.PubMedGoogle Scholar
  40. 40.
    Dirx MJ, van den Brandt PA, Goldbohm RA, Lumey LH (2003) Energy restriction early in life and colon carcinoma risk: results of The Netherlands Cohort Study after 7.3 years of follow-up. Cancer 97: 46–55.PubMedGoogle Scholar
  41. 41.
    Satia-Abouta J, Galanko JA, Potter JD, Ammerman A, Martin CF, Sandler RS (2003) Associations of total energy and macronutrients with colon cancer risk in African Americans and Whites: results from the North Carolina colon cancer study. Am J Epidemiol 158: 951–962.Google Scholar
  42. 42.
    Slattery ML, Potter J, Caan B, et al. (1997) Energy balance and colon cancer—beyond physical activity. Cancer Res 57: 75–80.PubMedGoogle Scholar
  43. 43.
    Slattery ML, Caan BJ, Benson J, Murtaugh M (2003) Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index. Nutr Cancer 46: 166–171.PubMedGoogle Scholar
  44. 44.
    Mao Y, Pan S, Wen SW, Johnson KC (2003) Physical inactivity, energy intake, obesity and the risk of rectal cancer in Canada. Int J Cancer 105: 831–837.PubMedGoogle Scholar
  45. 45.
    Levi F, Pasche C, Lucchini F, La VC (2002) Macronutrients and colorectal cancer: a Swiss case-control study. Ann Oncol 13: 369–373.PubMedGoogle Scholar
  46. 46.
    Franceschi S, La VC, Russo A, et al. (1998) Macronutrient intake and risk of colorectal cancer in Italy. Int J Cancer 76: 321–324.PubMedGoogle Scholar
  47. 47.
    Howe GR, Aronson KJ, Benito E, et al. (1997) The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies. Cancer Causes Control 8: 215–228.PubMedGoogle Scholar
  48. 48.
    Le ML, Wilkens LR, Kolonel LN, Hankin JH, Lyu LC (1997) Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res 57: 4787–4794.Google Scholar
  49. 49.
    Gerhardsson d, V, Hagman U, Steineck G, Rieger A, Norell SE (1990) Diet, body mass and colorectal cancer: a case-referent study in Stockholm. Int J Cancer 46: 832–838.Google Scholar
  50. 50.
    Freudenheim JL, Graham S, Marshall JR, Haughey BP, Wilkinson G (1990) A casecontrol study of diet and rectal cancer in western New York. Am J Epidemiol 131 : 612–624.PubMedGoogle Scholar
  51. 51.
    Graham S, Marshall J, Haughey B, et al. (1988) Dietary epidemiology of cancer of the colon in western New York. Am J Epidemiol 128: 490–503.PubMedGoogle Scholar
  52. 52.
    Boutron-Ruault MC, Senesse P, Meance S, Belghiti C, Faivre J (2001) Energy intake, body mass index, physical activity, and the colorectal adenoma-carcinoma sequence. Nutr Cancer 39: 50–57.PubMedGoogle Scholar
  53. 53.
    Gaard M, Tretli S, Loken EB (1996) Dietary factors and risk of colon cancer: a prospective study of 50,535 young Norwegian men and women. Eur J Cancer Prev 5: 445–454.PubMedGoogle Scholar
  54. 54.
    Stemmermann GN, Nomura AM, Heilbrun LK (1985) Cancer risk in relation to fat and energy intake among Hawaii Japanese: a prospective study. Princess Takamatsu Symp 16: 265–274.PubMedGoogle Scholar
  55. 55.
    Kato I, Akhmedkhanov A, Koenig K, Toniolo PG, Shore RE, Riboli E (1997) Prospective study of diet and female colorectal cancer: the New York University Women's Health Study. Nutr Cancer 28: 276–281.PubMedGoogle Scholar
  56. 56.
    Dirx MJ, van den Brandt PA, Goldbohm RA, Lumey LH (2001) Energy restriction in childhood and adolescence and risk of prostate cancer: results from the Netherlands Cohort Study. Am J Epidemiol 154: 530–537.PubMedGoogle Scholar
  57. 57.
    Platz EA (2002) Energy imbalance and prostate cancer. J Nutr 132: 3471S–3481S.PubMedGoogle Scholar
  58. 58.
    Platz EA, Leitzmann MF, Michaud DS, Willett WC, Giovannucci E (2003) Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study. Cancer Res 63: 8542–8548.PubMedGoogle Scholar
  59. 59.
    Hsieh LJ, Carter HB, Landis PK, et al. (2003) Association of energy intake with prostate cancer in a long-term aging study: Baltimore Longitudinal Study of Aging (United States). Urology 61: 297–301.PubMedGoogle Scholar
  60. 60.
    Kristal AR, Cohen JH, Qu P, Stanford JL (2002) Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev 11: 719–725.PubMedGoogle Scholar
  61. 61.
    Darlington GA, Kreiger N, Lightfoot N, Purdham J, Sass-Kortsak A (2007) Prostate cancer risk and diet, recreational physical activity and cigarette smoking. Chronic Dis Can 27: 145–153.PubMedGoogle Scholar
  62. 62.
    IARC Handbooks of Cancer Prevention (2002) Weight Control and Physical Activity. Lyons, France: International Agency for Research on Cancer.Google Scholar
  63. 63.
    Slattery ML (2004) Physical activity and colorectal cancer. Sports Med 34: 239–252.PubMedGoogle Scholar
  64. 64.
    Lee KJ, Inoue M, Otani T, Iwasaki M, Sasazuki S, Tsugane S (2007) Physical activity and risk of colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective study. Cancer Causes Control 18: 199–209.PubMedGoogle Scholar
  65. 65.
    Isomura K, Kono S, Moore MA, et al. (2006) Physical activity and colorectal cancer: the Fukuoka Colorectal Cancer Study. Cancer Sci 97: 1099–1104.PubMedGoogle Scholar
  66. 66.
    Mai PL, Sullivan-Halley J, Ursin G, et al. (2007) Physical activity and colon cancer risk among women in the California Teachers Study. Cancer Epidemiol Biomarkers Prev 16: 517–525.PubMedGoogle Scholar
  67. 67.
    Friedenreich C, Norat T, Steindorf K, et al. (2006) Physical activity and risk of colon and rectal cancers: the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 15: 2398–2407.PubMedGoogle Scholar
  68. 68.
    Larsson SC, Rutegard J, Bergkvist L, Wolk A (2006) Physical activity, obesity, and risk of colon and rectal cancer in a cohort of Swedish men. Eur J Cancer 42: 2590–2597.PubMedGoogle Scholar
  69. 69.
    Zhang Y, Cantor KP, Dosemeci M, Lynch CF, Zhu Y, Zheng T (2006) Occupational and leisure-time physical activity and risk of colon cancer by subsite. J Occup Environ Med 48: 236–243.PubMedGoogle Scholar
  70. 70.
    Steindorf K, Jedrychowski W, Schmidt M, et al. (2005) Case-control study of lifetime occupational and recreational physical activity and risks of colon and rectal cancer. Eur J Cancer Prev 14: 363–371.PubMedGoogle Scholar
  71. 71.
    Chao A, Connell CJ, Jacobs EJ, et al. (2004) Amount, type, and timing of recreational physical activity in relation to colon and rectal cancer in older adults: the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 13: 2187–2195.PubMedGoogle Scholar
  72. 72.
    Wei EK, Giovannucci E, Wu K, et al. (2004) Comparison of risk factors for colon and rectal cancer. Int J Cancer 108: 433–442.PubMedGoogle Scholar
  73. 73.
    Samad AK, Taylor RS, Marshall T, Chapman MA (2005) A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Dis 7: 204–213.PubMedGoogle Scholar
  74. 74.
    Calton BA, Lacey JV Jr, Schatzkin A, et al. (2006) Physical activity and the risk of colon cancer among women: a prospective cohort study (United States). Int J Cancer 119: 385–391.PubMedGoogle Scholar
  75. 75.
    Lund Nilsen TI, Vatten LJ (2002) Colorectal cancer associated with BMI, physical activity, diabetes, and blood glucose. IARC Sci Publ 156: 257–258.PubMedGoogle Scholar
  76. 76.
    Monninkhof EM, Elias SG, Vlems FA, et al. (2007) Physical activity and breast cancer: a systematic review. Epidemiology 18: 137–157.PubMedGoogle Scholar
  77. 77.
    Vainio H, Kaaks R, Bianchini F (2002) Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 11 Suppl 2: S94–100.PubMedGoogle Scholar
  78. 78.
    Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132: 3456S–3464S.PubMedGoogle Scholar
  79. 79.
    Lagerros YT, Hsieh SF, Hsieh CC (2004) Physical activity in adolescence and young adulthood and breast cancer risk: a quantitative review. Eur J Cancer Prev 13: 5–12.PubMedGoogle Scholar
  80. 80.
    Torti DC, Matheson GO (2004) Exercise and prostate cancer. Sports Med 34: 363–369.PubMedGoogle Scholar
  81. 81.
    Littman AJ, Kristal AR, White E (2006) Recreational physical activity and prostate cancer risk (United States). Cancer Causes Control 17: 831–841.PubMedGoogle Scholar
  82. 82.
    Nilsen TI, Romundstad PR, Vatten LJ (2006) Recreational physical activity and risk of prostate cancer: A prospective population-based study in Norway (the HUNT study). Int J Cancer 119: 2943–2947.PubMedGoogle Scholar
  83. 83.
    Zeegers MP, Dirx MJ, van den Brandt PA (2005) Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev 14: 1490–1495.PubMedGoogle Scholar
  84. 84.
    Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ, Willett WC (2005) A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med 165: 1005–1010.PubMedGoogle Scholar
  85. 85.
    Patel AV, Rodriguez C, Jacobs EJ, Solomon L, Thun MJ, Calle EE (2005) Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men. Cancer Epidemiol Biomarkers Prev 14: 275–279.PubMedGoogle Scholar
  86. 86.
    Norman A, Moradi T, Gridley G, et al. (2002) Occupational physical activity and risk for prostate cancer in a nationwide cohort study in Sweden. Br J Cancer 86: 70–75.PubMedGoogle Scholar
  87. 87.
    Friedenreich CM, McGregor SE, Courneya KS, Angyalfi SJ, Elliott FG (2004) Casecontrol study of lifetime total physical activity and prostate cancer risk. Am J Epidemiol 159: 740–749.PubMedGoogle Scholar
  88. 88.
    Pierotti B, Altieri A, Talamini R, et al. (2005) Lifetime physical activity and prostate cancer risk. Int J Cancer 114: 639–642.PubMedGoogle Scholar
  89. 89.
    Jian L, Shen ZJ, Lee AH, Binns CW (2005) Moderate physical activity and prostate cancer risk: a case-control study in China. Eur J Epidemiol 20: 155–160.PubMedGoogle Scholar
  90. 90.
    Voskuil DW, Monninkhof EM, Elias SG, Vlems FA, van Leeuwen FE (2007) Physical activity and endometrial cancer risk, a systematic review of current evidence. Cancer Epidemiol Biomarkers Prev 16: 639–648.PubMedGoogle Scholar
  91. 91.
    Friedenreich C, Cust A, Lahmann PH, et al. (2007) Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition. Int J Cancer 121: 347–355.PubMedGoogle Scholar
  92. 92.
    Matthews CE, Xu WH, Zheng W, et al. (2005) Physical activity and risk of endometrial cancer: a report from the Shanghai endometrial cancer study. Cancer Epidemiol Biomarkers Prev 14: 779–785.PubMedGoogle Scholar
  93. 93.
    Colbert LH, Lacey JV, Jr, Schairer C, Albert P, Schatzkin A, Albanes D (2003) Physical activity and risk of endometrial cancer in a prospective cohort study (United States). Cancer Causes Control 14: 559–567.PubMedGoogle Scholar
  94. 94.
    Furberg AS, Thune I (2003) Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer 104: 669–676.PubMedGoogle Scholar
  95. 95.
    Schouten LJ, Goldbohm RA, van den Brandt PA (2004) Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands Cohort Study. J Natl Cancer Inst 96: 1635–1638.PubMedGoogle Scholar
  96. 96.
    Littman AJ, Voigt LF, Beresford SA, Weiss NS (2001) Recreational physical activity and endometrial cancer risk. Am J Epidemiol 154: 924–933.PubMedGoogle Scholar
  97. 97.
    Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG, et al. (2000) Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control 11: 707–711.PubMedGoogle Scholar
  98. 98.
    Moradi T, Nyren O, Bergstrom R, et al. (1998) Risk for endometrial cancer in relation to occupational physical activity: a nationwide cohort study in Sweden. Int J Cancer 76: 665–670.PubMedGoogle Scholar
  99. 99.
    Moradi T, Weiderpass E, Signorello LB, Persson I, Nyren O, Adami HO (2000) Physical activity and postmenopausal endometrial cancer risk (Sweden). Cancer Causes Control 11: 829–837.PubMedGoogle Scholar
  100. 100.
    Goodman MT, Hankin JH, Wilkens LR, et al. (1997) Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 57: 5077–5085.PubMedGoogle Scholar
  101. 101.
    Hirose K, Tajima K, Hamajima N, et al. (1996) Subsite (cervix/endometrium)-specific risk and protective factors in uterus cancer. Jpn J Cancer Res 87: 1001–1009.PubMedGoogle Scholar
  102. 102.
    Kalandidi A, Tzonou A, Lipworth L, Gamatsi I, Filippa D, Trichopoulos D (1996) A case-control study of endometrial cancer in relation to reproductive, somatometric, and life-style variables. Oncology 53: 354–359.PubMedGoogle Scholar
  103. 103.
    Levi F, La VC, Negri E, Franceschi S (1993) Selected physical activities and the risk of endometrial cancer. Br J Cancer 67: 846–851.PubMedGoogle Scholar
  104. 104.
    Zheng W, Shu XO, McLaughlin JK, Chow WH, Gao YT, Blot WJ (1993) Occupational physical activity and the incidence of cancer of the breast, corpus uteri, and ovary in Shanghai. Cancer 71: 3620–3624.PubMedGoogle Scholar
  105. 105.
    Sturgeon SR, Brinton LA, Berman ML, et al. (1993) Past and present physical activity and endometrial cancer risk. Br J Cancer 68: 584–589.PubMedGoogle Scholar
  106. 106.
    Terry P, Baron JA, Weiderpass E, Yuen J, Lichtenstein P, Nyren O (1999) Lifestyle and endometrial cancer risk: a cohort study from the Swedish Twin Registry. Int J Cancer 82: 38–42.PubMedGoogle Scholar
  107. 107.
    Dosemeci M, Hayes RB, Vetter R, et al. (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4: 313–321.PubMedGoogle Scholar
  108. 108.
    Olson SH, Vena JE, Dorn JP, et al. (1997) Exercise, occupational activity, and risk of endometrial cancer. Ann Epidemiol 7: 46–53.PubMedGoogle Scholar
  109. 109.
    Friberg E, Mantzoros CS, Wolk A (2006) Physical activity and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev 15: 2136–2140.PubMedGoogle Scholar
  110. 110.
    Tardon A, Lee WJ, Delgado-Rodriguez M, et al. (2005) Leisure-time physical activity and lung cancer: a meta-analysis. Cancer Causes Control 16: 389–397.PubMedGoogle Scholar
  111. 111.
    Sinner P, Folsom AR, Harnack L, Eberly LE, Schmitz KH (2006) The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women's Health Study. Cancer Epidemiol Biomarkers Prev 15: 2359–2363.PubMedGoogle Scholar
  112. 112.
    Steindorf K, Friedenreich C, Linseisen J, et al. (2006) Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort. Int J Cancer 119: 2389–2397.PubMedGoogle Scholar
  113. 113.
    Bak H, Christensen J, Thomsen BL, et al. (2005) Physical activity and risk for lung cancer in a Danish cohort. Int J Cancer 116: 439–444.PubMedGoogle Scholar
  114. 114.
    Alfano CM, Klesges RC, Murray DM, et al. (2004) Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers. Cancer Epidemiol Biomarkers Prev 13: 2233–2241.PubMedGoogle Scholar
  115. 115.
    Kubik A, Zatloukal P, Tomasek L, et al. (2007) Interactions between smoking and other exposures associated with lung cancer risk in women: diet and physical activity. Neoplasma 54: 83–88.PubMedGoogle Scholar
  116. 116.
    Biesma RG, Schouten LJ, Dirx MJ, Goldbohm RA, van den Brandt PA (2006) Physical activity and risk of ovarian cancer: results from the Netherlands Cohort Study (The Netherlands). Cancer Causes Control 17: 109–115.PubMedGoogle Scholar
  117. 117.
    Hannan LM, Leitzmann MF, Lacey JV, Jr, et al. (2004) Physical activity and risk of ovarian cancer: a prospective cohort study in the United States. Cancer Epidemiol Biomarkers Prev 13: 765–770.PubMedGoogle Scholar
  118. 118.
    Chiaffarino F, Parazzini F, Bosetti C, et al. (2007) Risk factors for ovarian cancer histotypes. Eur J Cancer 43: 1208–1213.PubMedGoogle Scholar
  119. 119.
    Pan SY, Ugnat AM, Mao Y (2005) Physical activity and the risk of ovarian cancer: a case-control study in Canada. Int J Cancer 117: 300–307.PubMedGoogle Scholar
  120. 120.
    Riman T, Dickman PW, Nilsson S, Nordlinder H, Magnusson CM, Persson IR (2004) Some life-style factors and the risk of invasive epithelial ovarian cancer in Swedish women. Eur J Epidemiol 19: 1011–1019.PubMedGoogle Scholar
  121. 121.
    Zhang M, Lee AH, Binns CW (2003) Physical activity and epithelial ovarian cancer risk: a case-control study in China. Int J Cancer 105: 838–843.PubMedGoogle Scholar
  122. 122.
    Tavani A, Gallus S, La VC, et al. (2001) Physical activity and risk of ovarian cancer: an Italian case-control study. Int J Cancer 91: 407–411.PubMedGoogle Scholar
  123. 123.
    Cottreau CM, Ness RB, Kriska AM (2000) Physical activity and reduced risk of ovarian cancer. Obstet Gynecol 96: 609–614.PubMedGoogle Scholar
  124. 124.
    Pukkala E, Poskiparta M, Apter D, Vihko V (1993) Life-long physical activity and cancer risk among Finnish female teachers. Eur J Cancer Prev 2: 369–376.PubMedGoogle Scholar
  125. 125.
    Patel AV, Rodriguez C, Pavluck AL, Thun MJ, Calle EE (2006) Recreational physical activity and sedentary behavior in relation to ovarian cancer risk in a large cohort of US women. Am J Epidemiol 163: 709–716.PubMedGoogle Scholar
  126. 126.
    Weiderpass E, Margolis KL, Sandin S, et al. (2006) Prospective study of physical activity in different periods of life and the risk of ovarian cancer. Int J Cancer 118: 3153–3160.PubMedGoogle Scholar
  127. 127.
    Bertone ER, Newcomb PA, Willett WC, Stampfer MJ, Egan KM (2002) Recreational physical activity and ovarian cancer in a population-based case-control study. Int J Cancer 99: 431–436.PubMedGoogle Scholar
  128. 128.
    Anderson JP, Ross JA, Folsom AR (2004) Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health Study. Cancer 100: 1515ȓ1521.PubMedGoogle Scholar
  129. 129.
    Bertone ER, Willett WC, Rosner BA, et al. (2001) Prospective study of recreational physical activity and ovarian cancer. J Natl Cancer Inst 93: 942–948.PubMedGoogle Scholar
  130. 130.
    Lin Y, Kikuchi S, Tamakoshi A, et al. (2007) Obesity, physical activity and the risk of pancreatic cancer in a large Japanese cohort. Int J Cancer 120: 2665–2671.PubMedGoogle Scholar
  131. 131.
    Nothlings U, Wilkens LR, Murphy SP, Hankin JH, Henderson BE, Kolonel LN (2007) Body mass index and physical activity as risk factors for pancreatic cancer: the Multiethnic Cohort Study. Cancer Causes Control 18: 165–175.PubMedGoogle Scholar
  132. 132.
    Luo J, Iwasaki M, Inoue M, et al. (2007) Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–the JPHC study. Cancer Causes Control 18: 603–612.PubMedGoogle Scholar
  133. 133.
    Berrington de GA, Spencer EA, Bueno-de-Mesquita HB, et al. (2006) Anthropometry, physical activity, and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 15: 879–885.Google Scholar
  134. 134.
    Sinner PJ, Schmitz KH, Anderson KE, Folsom AR (2005) Lack of association of physical activity and obesity with incident pancreatic cancer in elderly women. Cancer Epidemiol Biomarkers Prev 14: 1571–1573.PubMedGoogle Scholar
  135. 135.
    Patel AV, Rodriguez C, Bernstein L, Chao A, Thun MJ, Calle EE (2005) Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. Cohort. Cancer Epidemiol Biomarkers Prev 14: 459–466.PubMedGoogle Scholar
  136. 136.
    Lee IM, Sesso HD, Oguma Y, Paffenbarger RS, Jr. (2003) Physical activity, body weight, and pancreatic cancer mortality. Br J Cancer 88: 679–683.PubMedGoogle Scholar
  137. 137.
    Lee IM, Paffenbarger RS, Jr (1994) Physical activity and its relation to cancer risk: a prospective study of college alumni. Med Sci Sports Exerc 26: 831–837.PubMedGoogle Scholar
  138. 138.
    Brownson RC, Chang JC, Davis JR, Smith CA (1991) Physical activity on the job and cancer in Missouri. Am J Public Health 81: 639–642.PubMedGoogle Scholar
  139. 139.
    Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D (2002) A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland). Cancer Causes Control 13: 417–426.PubMedGoogle Scholar
  140. 140.
    Michaud DS, Giovannucci E, W illett WC, Colditz GA, Stampfer MJ, Fuchs CS (2001) Physical activity, obesity, height, and the risk of pancreatic cancer. JAMA 286: 921–929.PubMedGoogle Scholar
  141. 141.
    Isaksson B, Jonsson F, Pedersen NL, Larsson J, Feychting M, Permert J (2002) Lifestyle factors and pancreatic cancer risk: a cohort study from the Swedish Twin Registry. Int J Cancer 98: 480–482.PubMedGoogle Scholar
  142. 142.
    Nilsen TI, Vatten LJ (2000) A prospective study of lifestyle factors and the risk of pancreatic cancer in Nord-Trondelag, Norway. Cancer Causes Control 11: 645–652.PubMedGoogle Scholar
  143. 143.
    Hanley AJ, Johnson KC, Villeneuve PJ, Mao Y (2001) Physical activity, anthropometric factors and risk of pancreatic cancer: results from the Canadian enhanced cancer surveillance system. Int J Cancer 94: 140–147.PubMedGoogle Scholar
  144. 144.
    Inoue M, Tajima K, Takezaki T, et al. (2003) Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HER-PACC). Int J Epidemiol 32: 257–262.PubMedGoogle Scholar
  145. 145.
    Eberle CA, Bracci PM, Holly EA (2005) Anthropometric factors and pancreatic cancer in a population-based case-control study in the San Francisco Bay area. Cancer Causes Control 16: 1235–1244.PubMedGoogle Scholar
  146. 146.
    van Dijk BA, Schouten LJ, Kiemeney LA, Goldbohm RA, van den Brandt PA (2004) Relation of height, body mass, energy intake, and physical activity to risk of renal cell carcinoma: results from the Netherlands Cohort Study. Am J Epidemiol 160: 1159–1167.PubMedGoogle Scholar
  147. 147.
    Bergstrom A, Terr y P, Lindblad P, et al. (2001) Physical activity and risk of renal cell cancer. Int J Cancer 92: 155–157.PubMedGoogle Scholar
  148. 148.
    Paffenbarger RS, Jr, Hyde RT, Wing AL (1987) Physical activity and incidence of cancer in diverse populations: a preliminary report. Am J Clin Nutr 45: 312–317.PubMedGoogle Scholar
  149. 149.
    Pan SY, DesMeules M, Morrison H, Wen SW (2006) Obesity, high energy intake, lack of physical activity, and the risk of kidney cancer. Cancer Epidemiol Biomarkers Prev 15: 2453–2460.PubMedGoogle Scholar
  150. 150.
    Mellemgaard A, Lindblad P, Schlehofer B, et al. (1995) International renal-cell cancer study. III. Role of weight, height, physical activity, and use of amphetamines. Int J Cancer 60: 350–354.PubMedGoogle Scholar
  151. 151.
    Mellemgaard A, Engholm G, McLaughlin JK, Olsen JH (1994) Risk factors for renalcell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors. Int J Cancer 56: 66–71.PubMedGoogle Scholar
  152. 152.
    Goodman MT, Morgenstern H, Wynder EL (1986) A case-control study of factors affecting the development of renal cell cancer. Am J Epidemiol 124: 926–941.PubMedGoogle Scholar
  153. 153.
    Wendy S, V, Stram DO, Nomura AM, Kolonel LN, Henderson BE (2007) Risk factors for renal cell cancer: The multiethnic cohort. Am J Epidemiol.Google Scholar
  154. 154.
    Mahabir S, Leitzmann MF, Pietinen P, Albanes D, Virtamo J, Taylor PR (2004) Physical activity and renal cell cancer risk in a cohort of male smokers. Int J Cancer 108: 600–605.PubMedGoogle Scholar
  155. 155.
    Bergstr om A, Moradi T, Lindblad P, Nyr en O, Adami HO, Wolk A (1999) Occupational physical activity and renal cell cancer: a nationwide cohort study in Sweden. Int J Cancer 83: 186–191.PubMedGoogle Scholar
  156. 156.
    Tavani A, Zucchetto A, Dal ML, et al. (2007) Lifetime physical activity and the risk of renal cell cancer. Int J Cancer 120: 1977–1980.PubMedGoogle Scholar
  157. 157.
    Menezes RJ, Tomlinson G, Kreiger N (2003) Physical activity and risk of renal cell carcinoma. Int J Cancer 107: 642–646.PubMedGoogle Scholar
  158. 158.
    Lindblad P, Wolk A, Bergstrom R, Persson I, Adami HO (1994) The role of obesity and weight fluctuations in the etiology of renal cell cancer: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 3: 631–639.PubMedGoogle Scholar
  159. 159.
    Yeter K, Rock CL, Pakiz B, Bardwell WA, Nichols JF, Wilfley DE (2006) Depressive symptoms, eating psychopathology, and physical activity in obese breast cancer survivors. Psychooncology 15: 453–462.PubMedGoogle Scholar
  160. 160.
    Milne HM, Gordon S, Guilfoyle A, Wallman KE, Courneya KS (2007) Association between physical activity and quality of life among Western Australian breast cancer survivors. Psychooncology.Google Scholar
  161. 161.
    Milne HM, Wallman KE, Gordon S, Courneya KS (2007) Effects of a combined aerobic and resistance exercise program in breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat.Google Scholar
  162. 162.
    Weitzen R, Tichler T, Kaufman B, Catane R, Shpatz Y (2006) [Body weight, nutritional factors and physical activity--their influence on prognosis after breast cancer diagnosis). Harefuah 145: 820–825, 861.PubMedGoogle Scholar
  163. 163.
    Holmes MD, Chen WY, Feskanich D, Kroenke CH, Colditz GA (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293: 2479–2486.PubMedGoogle Scholar
  164. 164.
    Pierce JP, Stefanick ML, Flatt SW, et al. (2007) Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity. J Clin Oncol 25: 2345–2351.PubMedGoogle Scholar
  165. 165.
    Meyerhardt JA, Giovannucci EL, Holmes MD, et al. (2006) Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol 24: 3527–3534.PubMedGoogle Scholar
  166. 166.
    Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. (2006) Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 24: 3535–3541.PubMedGoogle Scholar
  167. 167.
    Kirshbaum MN (2007) A review of the benefits of whole body exercise during and after treatment for breast cancer. J Clin Nurs 16: 104–121.PubMedGoogle Scholar
  168. 168.
    Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R (2005) Controlled physical activity trials in cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 14: 1588–1595.PubMedGoogle Scholar
  169. 169.
    Mao Y, Pan SY, Ugnat AM (2006) Obesity as a cancer risk factor: epidemiology. In: Awad AB, Bradford PG, eds. Nutrition and Cancer Prevention. Boca Raton: Taylor & Francis Group, pp. 541–563.Google Scholar
  170. 170.
    Carmichael AR, Bates T (2004) Obesity and breast cancer: a review of the literature. Breast 13: 85–92.PubMedGoogle Scholar
  171. 171.
    Bianchini F, Kaaks R, Vainio H (2002) Overweight, obesity, and cancer risk. Lancet ncol 3: 565–574.Google Scholar
  172. 172.
    Bergstrom A, Pisani P, Tenet V, Wolk A, Adami HO (2001) Overweight as an avoidable cause of cancer in Europe. Int J Cancer 91: 421–430.PubMedGoogle Scholar
  173. 173.
    Calle EE, Kaaks R (2004) Over weight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4: 579–591.PubMedGoogle Scholar
  174. 174.
    Lundqvist E, Kaprio J, Verkasalo PK, et al. (2007) Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins. Int J Cancer 121: 810–818.PubMedGoogle Scholar
  175. 175.
    Kuriyama S, Tsubono Y, Hozawa A, et al. (2005) Obesity and risk of cancer in Japan. Int J Cancer 113: 148–157.PubMedGoogle Scholar
  176. 176.
    Pan SY, Johnson KC, Ugnat AM, Wen SW, Mao Y (2004) Association of obesity and cancer risk in Canada. Am J Epidemiol 159: 259–268.PubMedGoogle Scholar
  177. 177.
    Har vie M, Hooper L, Howell AH (2003) Central obesity and breast cancer risk: a systematic review. Obes Rev 4: 157–173.PubMedGoogle Scholar
  178. 178.
    Car michael AR (2006) Obesity and prognosis of breast cancer. Obes Rev 7: 333–340.PubMedGoogle Scholar
  179. 179.
    Gunter MJ, Leitzmann MF (2006) Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. J Nutr Biochem 17: 145–156.PubMedGoogle Scholar
  180. 180.
    Pischon T, Lahmann PH, Boeing H, et al. (2006) Body size and risk of colon and rectal cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC). J Natl Cancer Inst 98: 920–931.PubMedGoogle Scholar
  181. 181.
    Adams KF, Leitzmann MF, Albanes D, et al. (2007) Body mass and colorectal cancer risk in the NIH-AARP cohort. Am J Epidemiol 166: 36–45.PubMedGoogle Scholar
  182. 182.
    Lukanova A, Bjor O, Kaaks R, et al. (2006) Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort. Int J Cancer 118: 458–466.PubMedGoogle Scholar
  183. 183.
    Samanic C, Chow WH, Gridley G, Jarvholm B, Fraumeni JF, Jr (2006) Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 17: 901–909.PubMedGoogle Scholar
  184. 184.
    Samanic C, Gridley G, Chow WH, Lubin J, Hoover RN, Fraumeni JF, Jr (2004) Obesity and cancer risk among white and black United States veterans. Cancer Causes Control 15: 35–43.PubMedGoogle Scholar
  185. 185.
    Oh SW, Yoon YS, Shin SA (2005) Ef fects of excess weight on cancer incidences depending on cancer sites and histologic findings among men: Korea National Health Insurance Corporation Study. J Clin Oncol 23: 4742–4754.PubMedGoogle Scholar
  186. 186.
    Rapp K, Schroeder J, Klenk J, et al. (2005) Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria. Br J Cancer 93: 1062–1067.PubMedGoogle Scholar
  187. 187.
    MacInnis RJ, English DR, Hopper JL, Haydon AM, Gertig DM, Giles GG (2004) Body size and composition and colon cancer risk in men. Cancer Epidemiol Biomarkers Prev 13: 553–559.PubMedGoogle Scholar
  188. 188.
    Terr y PD, Miller AB, Rohan TE (2002) Obesity and colorectal cancer risk in women. Gut 51: 191–194.PubMedGoogle Scholar
  189. 189.
    Terr y P, Giovannucci E, Bergkvist L, Holmberg L, Wolk A (2001) Body weight and colorectal cancer risk in a cohort of Swedish women: relation varies by age and cancer site. Br J Cancer 85: 346–349.PubMedGoogle Scholar
  190. 190.
    Slatter y ML, Ballard-Barbash R, Edwards S, Caan BJ, Potter JD (2003) Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control 14: 75–84.PubMedGoogle Scholar
  191. 191.
    Hou L, Ji BT, Blair A, et al. (2006) Body mass index and colon cancer risk in Chinese people: menopause as an effect modifier. Eur J Cancer 42: 84–90.PubMedGoogle Scholar
  192. 192.
    Lin J, Zhang SM, Cook NR, Rexrode KM, Lee IM, Buring JE (2004) Body mass index and risk of colorectal cancer in women (United States). Cancer Causes Control 15: 581–589.PubMedGoogle Scholar
  193. 193.
    MacInnis RJ, English DR, Hopper JL, Gertig DM, Haydon AM, Giles GG (2006) Body size and composition and colon cancer risk in women. Int J Cancer 118: 1496–1500.PubMedGoogle Scholar
  194. 194.
    MacInnis RJ, English DR, Haydon AM, Hopper JL, Gertig DM, Giles GG (2006) Body size and composition and risk of rectal cancer (Australia). Cancer Causes Control 17: 1291–1297.PubMedGoogle Scholar
  195. 195.
    Moore LL, Bradlee ML, Singer MR, et al. (2004) BMI and waist circumference as predictors of lifetime colon cancer risk in Framingham Study adults. Int J Obes Relat Metab Disord 28: 559–567.PubMedGoogle Scholar
  196. 196.
    Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC (1995) Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med 122: 327–334.PubMedGoogle Scholar
  197. 197.
    Sedjo RL, Byers T, Levin TR, et al. (2007) Change in body size and the risk of colorectal adenomas. Cancer Epidemiol Biomarkers Prev 16: 526–531.PubMedGoogle Scholar
  198. 198.
    Chung YW, Han DS, Park YK, et al. (2006) Association of obesity, serum glucose and lipids with the risk of advanced colorectal adenoma and cancer: a case-control study in Korea. Dig Liver Dis 38: 668–672.PubMedGoogle Scholar
  199. 199.
    Guilera M, Connelly-Frost A, Keku TO, Martin CF, Galanko J, Sandler RS (2005) Does physical activity modify the association between body mass index and colorec-tal adenomas? Nutr Cancer 51: 140–145.PubMedGoogle Scholar
  200. 200.
    Giovannucci E, Colditz GA, Stampfer MJ, Willett WC (1996) Physical activity, obesity, and risk of colorectal adenoma in women (United States). Cancer Causes Control 7: 253–263.PubMedGoogle Scholar
  201. 201.
    Honjo S, Kono S, Shinchi K, et al. (1995) The relation of smoking, alcohol use and obesity to risk of sigmoid colon and rectal adenomas. Jpn J Cancer Res 86: 1019–1026.PubMedGoogle Scholar
  202. 202.
    Shinchi K, Kono S, Honjo S, et al. (1994) Obesity and adenomatous polyps of the sig-moid colon. Jpn J Cancer Res 85: 479–484.PubMedGoogle Scholar
  203. 203.
    Bjorge T, Engeland A, Tretli S, Weiderpass E (2007) Body size in relation to cancer of the uterine corpus in 1 million Norwegian women. Int J Cancer 120: 378–383.PubMedGoogle Scholar
  204. 204.
    Calle EE, Rodriguez C, Walker-Thur mond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348: 1625–1638.PubMedGoogle Scholar
  205. 205.
    Chang SC, Lacey JV, Jr., Brinton LA, et al. (2007) Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study. Cancer Epidemiol Biomarkers Prev 16: 723–730.PubMedGoogle Scholar
  206. 206.
    Friedenreich C, Cust A, Lahmann PH, et al. (2007) Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition. Cancer Causes Control 18: 399–413.PubMedGoogle Scholar
  207. 207.
    Xu WH, Matthews CE, Xiang YB, et al. (2005) Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women. Am J Epidemiol 161: 939–947.PubMedGoogle Scholar
  208. 208.
    Trentham-Dietz A, Nichols HB, Hampton JM, Newcomb PA (2006) Weight change and risk of endometrial cancer. Int J Epidemiol 35: 151–158.PubMedGoogle Scholar
  209. 209.
    La VC, Franceschi S, Decarli A, Gallus G, Tognoni G (1984) Risk factors for endometrial cancer at different ages. J Natl Cancer Inst 73: 667–671.Google Scholar
  210. 210.
    Le ML, Wilkens LR, Mi MP (1991) Early-age body size, adult weight gain and endometrial cancer risk. Int J Cancer 48: 807–811.Google Scholar
  211. 211.
    Tornberg SA, Carstensen JM (1994) Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years. Br J Cancer 69: 358–361.PubMedGoogle Scholar
  212. 212.
    Xu W, Dai Q, Ruan Z, Cheng J, Jin F, Shu X (2002) Obesity at different ages and endometrial cancer risk factors in urban Shanghai, China. Zhonghua Liu Xing Bing Xue Za Zhi 23: 347–351.PubMedGoogle Scholar
  213. 213.
    Levi F, La VC, Negri E, Parazzini F, Franceschi S (1992) Body mass at different ages and subsequent endometrial cancer risk. Int J Cancer 50: 567–571.PubMedGoogle Scholar
  214. 214.
    Friberg E, Mantzoros CS, Wolk A (2007) Diabetes and risk of endometrial cancer: a population-based prospective cohort study. Cancer Epidemiol Biomarkers Prev 16: 276–280.PubMedGoogle Scholar
  215. 215.
    Baanders-van Halewyn EA, Blankenstein MA, Thijssen JH, de Ridder CM, de Waard F (1996) A comparative study of risk factors for hyperplasia and cancer of the endometrium. Eur J Cancer Prev 5: 105–112.Google Scholar
  216. 216.
    Swanson CA, Potischman N, Wilbanks GD, et al. (1993) Relation of endometrial cancer risk to past and contemporary body size and body fat distribution. Cancer Epidemiol Biomarkers Prev 2: 321–327.PubMedGoogle Scholar
  217. 217.
    Shu XO, Brinton LA, Zheng W, et al. (1992) Relation of obesity and body fat distribution to endometrial cancer in Shanghai, China. Cancer Res 52: 3865–3870.PubMedGoogle Scholar
  218. 218.
    Austin H, Austin JM, Jr, Partridge EE, Hatch KD, Shingleton HM (1991) Endometrial cancer, obesity, and body fat distribution. Cancer Res 51: 568–572.PubMedGoogle Scholar
  219. 219.
    Olson SH, Trevisan M, Marshall JR, et al. (1995) Body mass index, weight gain, and risk of endometrial cancer. Nutr Cancer 23: 141–149.PubMedGoogle Scholar
  220. 220.
    Bergstrom A, Hsieh CC, Lindblad P, Lu CM, Cook NR, Wolk A (2001) Obesity and renal cell cancer—a quantitative review. Br J Cancer 85: 984–990.PubMedGoogle Scholar
  221. 221.
    Dal ML, Zucchetto A, Tavani A, et al. (2007) Renal cell cancer and body size at different ages: an Italian multicenter case-control study. Am J Epidemiol 166: 582–591.Google Scholar
  222. 222.
    Bjorge T, Tretli S, Engeland A (2004) Relation of height and body mass index to renal cell carcinoma in two million Norwegian men and women. Am J Epidemiol 160: 1168–1176.PubMedGoogle Scholar
  223. 223.
    Chow WH, Gridley G, Fraumeni JF, Jr, Jarvholm B (2000) Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med 343: 1305–1311.PubMedGoogle Scholar
  224. 224.
    Yuan JM, Castelao JE, Gago-Dominguez M, Ross RK, Yu MC (1998) Hypertension, obesity and their medications in relation to renal cell carcinoma. Br J Cancer 77: 1508–1513.PubMedGoogle Scholar
  225. 225.
    Kubo A, Corley DA (2006) Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 15: 872–878.PubMedGoogle Scholar
  226. 226.
    Merr y AH, Schouten LJ, Goldbohm RA, van den Brandt PA (2007) Body mass index, height and risk of adenocarcinoma of the oesophagus and gastric cardia: a prospective cohort study. Gut 56: 1503–1511.PubMedGoogle Scholar
  227. 227.
    MacInnis RJ, English DR, Hopper JL, Giles GG (2006) Body size and composition and the risk of gastric and oesophageal adenocarcinoma. Int J Cancer 118: 2628–2631.PubMedGoogle Scholar
  228. 228.
    Ryan AM, Rowley SP, Fitzgerald AP, Ravi N, Reynolds JV (2006) Adenocarcinoma of the oesophagus and gastric cardia: male preponderance in association with obesity. Eur J Cancer 42: 1151–1158.PubMedGoogle Scholar
  229. 229.
    Chow WH, Blot WJ, Vaughan TL, et al. (1998) Body mass index and risk of adenocarcinomas of the esophagus and gastric cardia. J Natl Cancer Inst 90: 150–155.PubMedGoogle Scholar
  230. 230.
    MacInnis RJ, English DR (2006) Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control 17: 989–1003.PubMedGoogle Scholar
  231. 231.
    Giovannucci E, Liu Y, Platz EA, Stampfer MJ, Willett WC (2007) Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer 121: 1571–1578.PubMedGoogle Scholar
  232. 232.
    Gong Z, Agalliu I, Lin DW, Stanford JL, Kristal AR (2007) Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle-aged men. Cancer 109: 1192–1202.PubMedGoogle Scholar
  233. 233.
    Gong Z, Neuhouser ML, Goodman PJ, et al. (2006) Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev 15: 1977–1983.PubMedGoogle Scholar
  234. 234.
    Littman AJ, White E, Kristal AR (2007) Anthropometrics and prostate cancer risk. Am J Epidemiol 165: 1271–1279.PubMedGoogle Scholar
  235. 235.
    Rodriguez C, Freedland SJ, Deka A, et al. (2007) Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 16: 63–69.PubMedGoogle Scholar
  236. 236.
    Freedland SJ, Platz EA (2007) Obesity and prostate cancer: making sense out of apparently conflicting data. Epidemiol Rev 29: 88–97.PubMedGoogle Scholar
  237. 237.
    Andersson SO, Wolk A, Bergstrom R, et al. (1997) Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish constr uction workers. J Natl Cancer Inst 89: 385–389.PubMedGoogle Scholar
  238. 238.
    Rodriguez C, Patel AV, Calle EE, Jacobs EJ, Chao A, Thun MJ (2001) Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev 10: 345–353.PubMedGoogle Scholar
  239. 239.
    Snowdon DA, Phillips RL, Choi W (1984) Diet, obesity, and risk of fatal prostate cancer. Am J Epidemiol 120: 244–250.PubMedGoogle Scholar
  240. 240.
    Wright ME, Chang SC, Schatzkin A, et al. (2007) Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer 109: 675–684.PubMedGoogle Scholar
  241. 241.
    Lacey JV, Jr., Leitzmann M, Brinton LA, et al. (2006) Weight, height, and body mass index and risk for ovarian cancer in a cohort study. Ann Epidemiol 16: 869–876.PubMedGoogle Scholar
  242. 242.
    Beehler GP, Sekhon M, Baker JA, et al. (2006) Risk of ovarian cancer associated with BMI varies by menopausal status. J Nutr 136: 2881–286.PubMedGoogle Scholar
  243. 243.
    Hoyo C, Berchuck A, Halabi S, et al. (2005) Anthropometric measurements and epithelial ovarian cancer risk in African-American and White women. Cancer Causes Control 16: 955–963.PubMedGoogle Scholar
  244. 244.
    Peterson NB, Trentham-Dietz A, Newcomb PA, et al. (2006) Relation of anthropometric measurements to ovarian cancer risk in a population-based case-control study (United States). Cancer Causes Control 17: 459–467.PubMedGoogle Scholar
  245. 245.
    Olsen CM, Green AC, Whiteman DC, Sadeghi S, Kolahdooz F, Webb PM (2007) Obesity and the risk of epithelial ovarian cancer: a systematic review and meta-analysis. Eur J Cancer 43: 690–709.PubMedGoogle Scholar
  246. 246.
    Engeland A, Tretli S, Bjorge T (2003) Height, body mass index, and ovarian cancer: a follow-up of 1.1 million Norwegian women. J Natl Cancer Inst 95: 1244–1248.PubMedGoogle Scholar
  247. 247.
    Fairfield KM, Willett WC, Rosner BA, Manson JE, Speizer FE, Hankinson SE (2002) Obesity, weight gain, and ovarian cancer. Obstet Gynecol 100: 288–296.PubMedGoogle Scholar
  248. 248.
    Lubin F, Chetrit A, Freedman LS, et al. (2003) Body mass index at age 18 years and during adult life and ovarian cancer risk. Am J Epidemiol 157: 113–120.PubMedGoogle Scholar
  249. 249.
    Kuper H, Cramer DW, Titus-Ernstoff L (2002) Risk of ovarian cancer in the United States in relation to anthropometric measures: does the association depend on men-opausal status? Cancer Causes Control 13: 455–463.PubMedGoogle Scholar
  250. 250.
    Larsson SC, Orsini N, Wolk A (2007) Body mass index and pancreatic cancer risk: A meta-analysis of prospective studies. Int J Cancer 120: 1993–1998.PubMedGoogle Scholar
  251. 251.
    Fr yzek JP, Schenk M, Kinnar d M, Greenson JK, Garabrant DH (2005) The association of body mass index and pancreatic cancer in residents of southeastern Michigan, 1996–1999. Am J Epidemiol 162: 222–228.PubMedGoogle Scholar
  252. 252.
    Larsson SC, Permert J, Hakansson N, Naslund I, Bergkvist L, Wolk A (2005) Overall obesity, abdominal adiposity, diabetes and cigarette smoking in relation to the risk of pancreatic cancer in two Swedish population-based cohorts. Br J Cancer 93: 1310–1315.PubMedGoogle Scholar
  253. 253.
    Ansar y-Moghaddam A, Huxley R, Barzi F, et al. (2006) The effect of modifiable risk factors on pancreatic cancer mortality in populations of the Asia-Pacific region. Cancer Epidemiol Biomarkers Prev 15: 2435–2440.PubMedGoogle Scholar
  254. 254.
    Wolk A, Gridley G, Svensson M, et al. (2001) A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 12: 13–21.PubMedGoogle Scholar
  255. 255.
    Moller H, Mellemgaard A, Lindvig K, Olsen JH (1994) Obesity and cancer risk: a Danish record-linkage study. Eur J Cancer 30A: 344–350.PubMedGoogle Scholar
  256. 256.
    Okasha M, McCarron P, McEwen J, Smith GD (2002) Body mass index in young adulthood and cancer mortality: a retrospective cohort study. J Epidemiol Community Health 56: 780–784.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Sai Yi Pan
    • 1
  • Marie DesMeules
    • 1
  1. 1.Public Health Agency of CanadaCentre for Chronic Disease Prevention and ControlOttawaCanada

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