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Treatment of Mice with Retinoids In Vivo and In Vitro

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Part of the book series: METHODS IN MOLECULAR BIOLOGY™ ((MIMB,volume 461))

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References

  1. Moore T (1957) Vitamin A. Elsevier, Amsterdam.

    Google Scholar 

  2. Mangelsdorf DJ, Umesono K, Evans RM (1994) The retinoid receptors. In: Sporn MB, Roberts AB, Goodman DS (eds) The retinoids: biology, chemistry and medicine (2nd ed,). Raven, New York, pp. 319–349.

    Google Scholar 

  3. Morriss GM (1972) Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A. J Anat 113:241–250.

    CAS  PubMed  Google Scholar 

  4. Morriss GM, Steele CE (1977) Comparison of the effects of retinol and retinoic acid on postimplantation rat embryos in vitro. Teratology 15:109–120.

    Article  CAS  PubMed  Google Scholar 

  5. Nau H (1994) Retinoid teratogenesis: toxicokinetics and structure specificity. In: Bolt HM, Hellman B, Denker L (eds) Use of mechanistic information in risk assessment (Archives in Toxicology, Supplement 16), Springer-Verlag, Berlin, pp. 118–127.

    Google Scholar 

  6. Ruberte E, Doll P, Chambon P, Morriss-Kay G (1991) Retinoic-acid receptors and cellular binding proteins, II. Their differential pattern of transcription during early morphogenesis in mouse embryos. Development 111:45–60.

    CAS  PubMed  Google Scholar 

  7. Båvik, C, Ward SJ, Ong DE (1997) Identification of a mechanism to localize generation of retinoic acid in rat embryos. Mech Dev 69:155–167.

    Article  PubMed  Google Scholar 

  8. Gustafson A-L, Dencker L, Eriksson U (1993) Non-overlapping expression of CRBP I and CRABP I during pattern formation of limbs and craniofacial structures in the early mouse embryo. Development 117:451–460.

    CAS  PubMed  Google Scholar 

  9. Creech-Kraft J, Löfberg B, Chahoud I, Bochert G, Nau H (1989) Teratogenicity and placental transfer of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low oral dose during organogenesis in mice. Toxicol Appl Pharmacol 100:162–176.

    Article  CAS  PubMed  Google Scholar 

  10. Ward SJ, Morriss-Kay GM (1995) Distribution of all-trans-, 13-cis and 9-cis-retinoic acid to whole rat embryos and maternal serum following oral administration of a teratogenic dose of all-trans-retinoic acid. Pharmacol Toxicol 76:196–201.

    Article  CAS  PubMed  Google Scholar 

  11. Klug S, Creech-Kraft J, Wildi E, Merker H-J, Persaud TVN, Nau H, Neubert, D. (1989) Influence of 13-cis and all-trans retinoic acid on rat embryonic development in vitro: correlation with isomerisation and drug transfer to the embryo. Arch Toxicol 63:185–192.

    Article  CAS  PubMed  Google Scholar 

  12. Bryant S V, Gardiner DM (1992) Retinoic acid, local cell-cell interactions, and pattern formation in vertebrate limbs. Dev Biol 152:1–25.

    Article  CAS  PubMed  Google Scholar 

  13. Wood HB, Pall GS, Morriss-Kay GM (1994) Exposure to retinoic acid before or after the onset of somitogenesis reveals separate effects on rhombomeric segmentation and 3 HoxB gene expression domains. Development 120:2279–2285.

    CAS  PubMed  Google Scholar 

  14. Wood HB, Ward SJ, Morriss-Kay GM (1996) Effects of retinoic acid on skeletal pattern, 5 HoxD gene expression, and RAR-£]2/£]4 promoter activity in embryonic mouse limbs. Dev Genet 18:74–84.

    Article  Google Scholar 

  15. Chen W-H, Morriss-Kay GM, Copp A (l995) Genesis and prevention of spinal neural tube defects in the curly tail mutant mouse: involvement of retinoic acid and its nuclear receptors RAR-£\ and RAR-£ ˆ. Development 121:681–691.

    Google Scholar 

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Morriss-Kay, G.M. (2008). Treatment of Mice with Retinoids In Vivo and In Vitro. In: Sharpe, P.T., Mason, I. (eds) Molecular Embryology. METHODS IN MOLECULAR BIOLOGY™, vol 461. Humana Press. https://doi.org/10.1007/978-1-60327-483-8_4

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  • DOI: https://doi.org/10.1007/978-1-60327-483-8_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-58829-431-9

  • Online ISBN: 978-1-60327-483-8

  • eBook Packages: Springer Protocols

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