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Bioinformatics pp 105–122Cite as

Analysis of Mass Spectrometry Data in Proteomics

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Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 453))

Abstract

The systematic study of proteins and protein networks, that is, proteomics, calls for qualitative and quantitative analysis of proteins and peptides. Mass spectrometry (MS) is a key analytical technology in current proteomics and modern mass spectrometers generate large amounts of high-quality data that in turn allow protein identification, annotation of secondary modifications, and determination of the absolute or relative abundance of individual proteins. Advances in mass spectrometryûdriven proteomics rely on robust bioinformatics tools that enable large-scale data analysis. This chapter describes some of the basic concepts and current approaches to the analysis of MS and MS/MS data in proteomics.

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Acknowledgments

R.M was supported by the EU TEMBLOR (IntAct) project and by a Carlsberg Foundation Fellowship. O.N.J. is a Lundbeck Foundation Research Professor and the recipient of a Young Investigator Award from the Danish Natural Science Research Council.

Author information

Authors and Affiliations

  1. CIC bioGUNE, Bilbao, Spain

    Rune Matthiesen

  2. Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark

    Ole N. Jensen

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  1. Rune Matthiesen
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  2. Ole N. Jensen
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Editor information

Editors and Affiliations

  1. School of Mathematical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia

    Jonathan M. Keith PhD

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© 2008 Humana Press, a part of Springer Science+Business Media, LLC

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Matthiesen, R., Jensen, O.N. (2008). Analysis of Mass Spectrometry Data in Proteomics. In: Keith, J.M. (eds) Bioinformatics. Methods in Molecular Biology™, vol 453. Humana Press. https://doi.org/10.1007/978-1-60327-429-6_4

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  • DOI: https://doi.org/10.1007/978-1-60327-429-6_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-428-9

  • Online ISBN: 978-1-60327-429-6

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