Approaches to Genetic Linkage Analysis

  • M. Dawn TeareEmail author
Part of the Methods in Molecular Biology book series (MIMB, volume 713)


Genetic linkage analysis concerns the estimation of genetic distance between two or more genetic loci. In genetic epidemiology, it is predominantly used to identify, or map, a genetic locus that is associated with quantitative trait variation or, in the case of binary or discrete traits, modification of the risk of being affected with a disease or phenotype. Linkage analysis uses a panel of reference genetic markers to track the segregation of genomic segments within families or sets of relatives. Individuals within the families must be measured for the trait, and often the families have been selected because they segregate the phenotype of interest.

Key words

Human genetic linkage Recombination fraction Allelic segregation Model-based linkage analysis Model-free linkage analysis 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Health Services Research, School of Health and Related ResearchUniversity of SheffieldSheffieldUK

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