Terminology, Concepts, and Models in Genetic Epidemiology

  • M. Dawn Teare
  • Mauro F. Santibàñez Koref
Part of the Methods in Molecular Biology book series (MIMB, volume 713)


Genetic epidemiology brings together approaches and techniques developed in mathematical genetics and statistics, medical genetics, quantitative genetics, and epidemiology. In the 1980s, the focus was on the mapping and identification of genes where defects had large effects at the individual level. More recently, statistical and experimental advances have made possible to identify and characterise genes associated with small effects at the individual level. In this chapter, we provide a brief outline of the models, concepts, and terminology used in genetic epidemiology.

Key words

Population genetics Mendelian segregation Kinship Identity by descent Genetic components of variance 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • M. Dawn Teare
    • 1
  • Mauro F. Santibàñez Koref
    • 2
  1. 1.Health Services Research, School of Health and Related ResearchUniversity of SheffieldSheffieldUK
  2. 2.Institute of Human GeneticsUniversity of NewcastleNewcastle upon TyneUK

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