Aggregation Effect in Microarray Data Analysis
Inferring gene regulatory networks from microarray data has become a popular activity in recent years, resulting in an ever-increasing volume of publications. There are many pitfalls in network analysis that remain either unnoticed or scantily understood. A critical discussion of such pitfalls is long overdue. Here we discuss one feature of microarray data the investigators need to be aware of when embarking on a study of putative associations between elements of networks and pathways.
Key wordsMicroarray data Networks Pathways Genetic pathways
The study was supported by Grant MSM 0021620839 of the Ministry of Education, Czech Republic.