Abstract
The cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain responses allowing assessment to analgesic medications. However, analgesic variability to various medications has been observed. A recent study suggests that methodological discrepancies may contribute to such inconsistencies. The model may be more reproducible by utilizing consistent protocols.
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References
Fruhstorfer H, Lindblom U (1983) Vascular participation in deep cold pain. Pain 17(3):235–241
Compton P, Charuvastra VC, Ling W (2003) Effect of oral ketorolac and gender on human cold pressor pain tolerance. Clin Exp Pharmacol Physiol 30(10):759–763
Yuan CS, Karrison T, Wu JA, Lowell JP, Lynch JP, Foss JF (1998) Dose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial. Clin Pharmacol Ther 63(3):379–383
Jones SF, McQuay HJ, Moore RA, Hand CW (1988) Morphine and Ibuprofen compared using the cold pressor test. Pain 34(2):117–122
Ashton H, Ebenezer I, Golding JF, Thompson JW (1984) Effects of acupuncture and transcutaneous electrical nerve stimulation on cold-induced pain in normal subjects. J Psychosom Res 28:301–308
Enggard TP, Klitgaard NA, Gram LF, Arendt-Nielsen L, Sindrup SH (2001) Specific effect of venlafaxine on single and repetitive experimental painful stimuli in humans. Clin Pharmcol Ther 69(4):245–251
Enggard TP, Poulsen L, Arendt-Nielsen L, Hansen SH, Bjornsdottir I, Gram LF, Sindrup SH (2001) The analgesic effect of codeine as compared to imipramine in different human experimental pain models. Pain 92(1-2):277–282
Eckhardt K, Ammon S, Hofmann U, Riebe A, Gugeler N, Mikus G (2000) Gabapentin enhances the analgesic effect of morphine in healthy volunteers. Anesth Analg 91(1):185–191
Mitchell LA, MacDonald RA, Brodie EE (2004) Temperature and the cold pressor test. J Pain 5(4):233–237
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Modir, J.G., Wallace, M.S. (2010). Human Experimental Pain Models 2: The Cold Pressor Model. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_13
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DOI: https://doi.org/10.1007/978-1-60327-323-7_13
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Publisher Name: Humana Press, Totowa, NJ
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