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Tissue Microarrays as a Tool in the Discovery and Validation of Predictive Biomarkers

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Book cover Molecular Profiling

Part of the book series: Methods in Molecular Biology ((MIMB,volume 823))

Abstract

The tissue microarray (TMA) is the embodiment of high-throughput pathology. The platform combines tens to hundreds of tissue samples on a single microscope slide for interrogation with routine molecular pathology tools. TMAs have enabled the rapid and cost-effective screening of biomarkers for diagnostic, prognostic, and predictive utility. Most commonly applied to the field of oncology, the TMA has accelerated the development of new biomarkers, and is emerging as an essential tool in the discovery and validation of tissue biomarkers for use in personalized medicine. This chapter provides an overview of TMA technology and highlights the advantages of using TMAs as tools toward rapid introduction of new biomarkers for clinical use.

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Author information

Authors and Affiliations

  1. Tissue Array Research Program/Laboratory of Pathology, National Institutes of Health/National Cancer Institute, Bethesda, MD, USA

    Stephen M. Hewitt

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  1. Stephen M. Hewitt
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Correspondence to Stephen M. Hewitt .

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Editors and Affiliations

  1. Center for Applied Proteomics and, George Mason University, University Blvd. 10900, Manassas, 20110, Virginia, USA

    Virginia Espina

  2. Center for Applied Proteomics &, George Mason University, University Blvd. 10900, Manassas, 20110, Virginia, USA

    Lance A. Liotta

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Hewitt, S.M. (2012). Tissue Microarrays as a Tool in the Discovery and Validation of Predictive Biomarkers. In: Espina, V., Liotta, L. (eds) Molecular Profiling. Methods in Molecular Biology, vol 823. Humana Press. https://doi.org/10.1007/978-1-60327-216-2_13

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  • DOI: https://doi.org/10.1007/978-1-60327-216-2_13

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-215-5

  • Online ISBN: 978-1-60327-216-2

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