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Detecting and Measuring Free Gadolinium in Nanoparticles for MRI Imaging

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Characterization of Nanoparticles Intended for Drug Delivery

Part of the book series: Methods in Molecular Biology ((MIMB,volume 697))

Abstract

This chapter describes a method for the measurement of free gadolinium in nanoparticle samples. Conjugation of a gadolinium-chelate to a nanoparticle allows the particle’s distribution to be imaged via magnetic resonance imaging (MRI). Free (unchelated) gadolinium is a known toxin, being a heavy metal, and may contribute towards total gadolinium concentration. Determining the amount of free gadolinium is therefore an important aspect of the preclinical characterization of gadolinium-chelate MRI imaging agent nanoparticles.

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Reference

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Acknowledgment

This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract N01-CO-12400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

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Authors and Affiliations

  1. Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC – Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA

    Jeffrey D. Clogston & Anil K. Patri

Authors
  1. Jeffrey D. Clogston
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  2. Anil K. Patri
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Editor information

Editors and Affiliations

  1. SAIC-Frederick, Inc., Nanotechnology Characterization Lab, National Cancer Institute at Frederick, Boyles Street 1050, Frederick, 21702, Maryland, USA

    Scott E. McNeil

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© 2011 Springer Science+Business Media, LLC

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Clogston, J.D., Patri, A.K. (2011). Detecting and Measuring Free Gadolinium in Nanoparticles for MRI Imaging. In: McNeil, S. (eds) Characterization of Nanoparticles Intended for Drug Delivery. Methods in Molecular Biology, vol 697. Humana Press. https://doi.org/10.1007/978-1-60327-198-1_10

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  • DOI: https://doi.org/10.1007/978-1-60327-198-1_10

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-197-4

  • Online ISBN: 978-1-60327-198-1

  • eBook Packages: Springer Protocols

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