The pathophysiological mechanisms after subarachnoid hemorrhage (SAH) may be divided in an acute phase after the bleeding, which includes increased intracranial pressure, reduced cerebral blood flow (CBF), and delayed consequences of the subarachnoid blood clot. The subarachnoid blood infusion in rat injection models could be classified in to volume and pressure-dependent and furthermore in to single or double hemorrhage. Investigating the acute phase pressure-dependent models seems to mimic the pathological sequel superior to volume dependent. However, the development of delayed mechanisms, like a reduced CBF due to cerebral vasospasm or other pathological mechanisms seems mainly to be dependent on the amount and the duration of the subarachnoid blood. Accordingly, the double cisterna magna blood injection model will be presented in this chapter, in which a sufficient subarachnoidal blood distribution and contact time could be achieved with a reduced acute phase effect. Therefore, this model seems to be predisposed for investigation on delayed consequences of SAH.
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Vatter, H., Gueresir, E., Seifert, V. (2009). Blood Injection Subarachnoid Hemorrhage Rat Model. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_22
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