Skip to main content
SpringerLink
Log in
Book cover

Animal Models of Acute Neurological Injuries pp 231–246Cite as

Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits

  • Protocol

Part of the book series: Springer Protocols Handbooks ((SPH))

Rabbits, like humans, are perinatal brain developers. The model of uterine ischemia mimics acute placental insufficiency states in humans such as placental abruption. A detailed description of the fetal model is presented. Following fetal hypoxia-ischemia, movement disorders are observed in postnatal rabbit kits akin to those observed in cerebral palsy in humans.

This is a preview of subscription content, log in via an institution.

Protocol
USD   49.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Springer Nature is developing a new tool to find and evaluate Protocols. Learn more

References

  1. Harel S, Shapira Y, Hartzler J, Teng EL, Quiligan E, Van Der Meulen J P. Neuromotor development in relation to birth weight in rabbits. Biol Neonate 1978; 33(1–2):1–7.

    PubMed  CAS  Google Scholar 

  2. Matsuda Y, Maeda T, Kouno S. Comparison of neonatal outcome including cerebral palsy between abruptio placentae and placenta previa. Eur J Obstet Gynecol Reprod Biol 2003; 106(2):125–129.

    Article  PubMed  Google Scholar 

  3. Iwasa H, Aono T, Fukuzawa K. Protective effect of vitamin E on fetal distress induced by ischemia of the uteroplacental system in pregnant rats. Free Radic Biol Med 1990; 8(4):393–400.

    Article  PubMed  CAS  Google Scholar 

  4. Derrick M, Luo NL, Bregman JC, et al. Preterm fetal hypoxia-ischemia causes hypertonia and motor deficits in the neonatal rabbit: a model for human cerebral palsy? J Neurosci 2004; 24:24–34.

    Article  PubMed  CAS  Google Scholar 

  5. Tan S, Drobyshevsky A, Jilling T, et al. Model of cerebral palsy in the perinatal rabbit. J Child Neurol 2005; 20(12):972–979.

    Article  PubMed  Google Scholar 

  6. Suckow MA, Douglas FA. The Laboratory Rabbit. CRC Press, Boca Raton, FL, 1997.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Evanston Northwestern Healthcare, Evanston, IL, USA

    X. Ji

  2. Department of Pediatrics, Evanston Northwestern Healthcare and Northwestern University, Evanston, IL, USA

    M. Derrick & S. Tan

Authors
  1. X. Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Derrick
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Tan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen M.D.

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu M.D., Ph.D.

  3. Spinal Cord and Brain Injury Research Group Stark Neurosciences Research Institute Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Xiao-Ming Xu M.D., Ph.D.

  4. Department of Physiology and Pharmacology Department of Neurosurgery Department of Anesthesiology, Loma Linda University Medical School, Loma Linda, CA, USA

    John H. Zhang M.D., Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Humana Press, a part of Springer Science + Business Media, LLC

About this protocol

Cite this protocol

Ji, X., Derrick, M., Tan, S. (2009). Cerebral Palsy Model of Uterine Ischemia in Pregnant Rabbits. In: Chen, J., Xu, Z.C., Xu, XM., Zhang, J.H. (eds) Animal Models of Acute Neurological Injuries. Springer Protocols Handbooks. Humana Press. https://doi.org/10.1007/978-1-60327-185-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-60327-185-1_19

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-184-4

  • Online ISBN: 978-1-60327-185-1

  • eBook Packages: Springer Protocols

Publish with us

Policies and ethics

Search

Navigation